Current Journal of Neurology

Original Article

Evaluation of obsessive-compulsive disorder prevalence in Iranian patients with multiple sclerosis and its relationship with demographic characteristics

Ali Keyhani; Mohammad Javad Shabani; Farnaz Etesam; Nasim Rezaeimanesh; Amirreza Azimi; Abdorreza Naser Moghadasi

Volume 22, Issue 4 , October 2023, Pages 204-209

https://doi.org/10.18502/cjn.v22i4.14523

Abstract

Background: The present study examined the prevalence of obsessive-compulsive disorder (OCD) among Iranian patients with multiple sclerosis (MS) and the relationship between OCD and the patient’s demographic characteristics.Methods: The present study used a cluster sampling method to randomly select ... Read More Background: The present study examined the prevalence of obsessive-compulsive disorder (OCD) among Iranian patients with multiple sclerosis (MS) and the relationship between OCD and the patient’s demographic characteristics.Methods: The present study used a cluster sampling method to randomly select 297 patients with MS from the patients referred to the MS Clinic and Research Center of Sina University Hospital, Tehran, Iran, during 2018-2019. To gather the required data, a questionnaire consisting of demographic characteristics and disease information sections was used. Moreover, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Obsessive-Compulsive Inventory-Revised (OCI-R), and Hospital Anxiety and Depression Scale (HADS) were employed in the present study. The comparison of qualitative and quantitative values between OCD-positive and negative groups was examined with chi-square test and independent samples t-test, respectively. Binary logistic regression was used as multivariate modeling to adjust the effects of potential confounders that could distort the relation of OCD with intended variables. Data were analyzed using SPSS software. The significance level was considered lower than 0.05.Results: Of the total of 297 patients, 77.8% were women. Moreover, analysis of the data obtained from the HADS questionnaire revealed that 11.44% (n = 34) and 15.15% (n = 45) of patients had severe depression and severe anxiety, respectively. The results of Y-BOCS indicated that the prevalence of severe OCD among patients was 19.9%. The OCI-R questionnaire revealed that the prevalence of OCD was 47.8%, which was consistent with the total of moderate, severe, and extreme values of Y-BOCS (47.9%). Furthermore, the subscales of ordering-arranging with 69 patients (22.9%) and obsessing with 46 patients (15.5%) indicated the highest frequencies as compared to other subscales. Moreover, OCD had a significant relationship with depression, anxiety, and type of MS in this regard.Conclusion: In this study, the prevalence rate of OCD among patients with MS was higher than its rate among the general population.

Original Article

Evaluation of risk factors for recurrence of cutaneous adverse reactions due to anti-seizure medications in children: A retrospective study

Çağatay Günay; Gamze Sarıkaya Uzan; Suna Asilsoy; Nevin Uzuner; Özge Kangallı; Semra Hız Kurul; Uluc Yiş

Volume 22, Issue 4 , October 2023, Pages 210-216

https://doi.org/10.18502/cjn.v22i4.14524

Abstract

Background: Cutaneous adverse reactions (CARs) are one of the most important reasons for anti-seizure medication (ASM) discontinuation in epilepsy. However, such discontinuations can cause an increase in seizures. This study investigates the risk factors for ASM-related rash recurrence in children.Methods: ... Read More

Original Article

Social support and anxiety correlation with resilience in patients with multiple sclerosis during COVID-19 pandemic

Vahid Shaygannejad; Omid Mirmosayyeb; Aysa Shaygannejad; Saeed Vaheb; Sara Bagherieh; Mozhdeh Askari; Mahsa Ghajarzadeh

Volume 22, Issue 4 , October 2023, Pages 217-220

https://doi.org/10.18502/cjn.v22i4.14525

Abstract

Background: Social support and anxiety are essential for patients with chronic diseases such as multiple sclerosis (MS). During coronavirus disease 2019 (COVID-19) pandemic, the psychological well-being of subjects with MS was an important issue, and we designed this study to assess anxiety, resilience, ... Read More Background: Social support and anxiety are essential for patients with chronic diseases such as multiple sclerosis (MS). During coronavirus disease 2019 (COVID-19) pandemic, the psychological well-being of subjects with MS was an important issue, and we designed this study to assess anxiety, resilience, and social support in these patients during COVID-19 pandemic stage.Methods: We used convenience sampling for this study. Inclusion criteria were definite diagnosis of MS based on McDonald criteria and age more than 18 years. Two hundred patients with MS were enrolled. Subjects were asked to fill out valid and reliable Persian versions of Connor-Davidson Resilience Scale (CD-RISC), Beck Anxiety Inventory (BAI), and Perceived Social Support Scale. We also collected demographic data (age, sex, marital status, and occupation), disease duration, and disability level [Expanded Disability Status Scale (EDSS)]. Continuous variables were presented as mean ± standard deviation (SD) (except for EDSS, as its distribution was not normal), and categorical variables were presented as frequencies. Correlation coefficients were calculated. We did a subgroup analysis and compared patients with BAI less than 30 and more than 30 (severe anxiety). A P-value less than 0.05 was considered significant.Results: Mean age and mean duration of the disease were 36.5 ± 9.3 and 6.2 ± 5.4 years, respectively. Mean BAI, social support, and resilience scores were 33.8 ± 11.4, 65.7 ± 16.7, and 62.5 ± 19.4, respectively. There was a significant positive correlation between resilience and social support scales (r = 0.44, P < 0.001), and also a significant negative correlation between resilience and BAI (r = -0.31, P < 0.001). Patients with severe anxiety (BAI > 30) had lower social support scores and resilience (social support: 70.3 ± 13.1 vs. 61.5 ± 18.6, P < 0.001; resilience: 57.3 ± 17.0 vs. 68.2 ± 19.6, P < 0.001) compared to patients with BAI ≤ 30. By considering resilience score as the dependent variable and other variables as independent variables, we found that BAI and social support scores were independent predictors.Conclusion: Social support and anxiety are independent predictors of resilience during COVID-19 pandemic in patients with MS.

Original Article

Plasma neurofilament light chain associated with impaired regional cerebral blood flow in healthy individuals

Fardin Nabizadeh; Richard T. Ward; Mohammad Balabandian; Samuel Berchi Kankam; Mahsa Pourhamzeh

Volume 22, Issue 4 , October 2023, Pages 221-230

https://doi.org/10.18502/cjn.v22i4.14526

Abstract

Background: Recent findings suggest that the plasma axonal structural protein, neurofilament light (NFL) chain, may serve as a potential blood biomarker for early signs of neurodegenerative diseases, such as Alzheimer’s disease (AD). Given the need for early detection of neurodegenerative disorders, ... Read More Background: Recent findings suggest that the plasma axonal structural protein, neurofilament light (NFL) chain, may serve as a potential blood biomarker for early signs of neurodegenerative diseases, such as Alzheimer’s disease (AD). Given the need for early detection of neurodegenerative disorders, the current study investigated the associations between regional cerebral blood flow (rCBF) in brain regions associated with neurodegenerative disorders and memory function with plasma NFL in AD, mild cognitive impairment (MCI), and healthy controls (HCs).Methods: We recruited 29 AD, 76 MCI, and 39 HCs from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database in the current cross-sectional study. We used Pearson’s correlation models adjusted for the effect of age, sex, and APOE genotype to investigate the association between plasma NFL and rCBF.Results: We found non-significant differences in age (F(2, 141) = 1.304; P = 0.275) and years of education (F(2, 141) = 0.013; P = 0.987). Additionally, we found significant differences between groups in terms of MMSE scores (F(2, 141) = 100.953; P < 0.001). Despite the observation of significantly reduced rCBF in AD and MCI groups versus HCs, we did not detect significant differences in plasma NFL between these groups. We found significant negative associations between plasma NFL and rCBF in various AD-related regions, these findings were only observed after analyses in all participants, and were observed in HCs alone and no significant associations were observed in the AD or MCI groups.Conclusion: These outcomes add to our current understanding surrounding the use of rCBF and plasma NFL biomarkers as tools for early detection and diagnosis of neurodegenerative diseases. A conclusion might be that the association between NFL and impaired rCBF exists before the clinical symptoms appear. Further longitudinal studies with a large sample size should be performed to examine the correlation between plasma NFL and rCBF in order to understand these complex relationships.

Original Article

On genotype-phenotype relationship of dystrophinopathies among Iranian population

Keivan Basiri; Maryam Alizadeh; Behnaz Ansari; Majid Ghasemi; Mohsen Kheradmand; Maryam Sedghi

Volume 22, Issue 4 , October 2023, Pages 231-237

https://doi.org/10.18502/cjn.v22i4.14528

Abstract

Background: Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are inherited X-linked disorders resulting from alterations in the dystrophin gene. Genotype-phenotype matching studies have revealed a link between disease severity, the amount of muscle dystrophin, and the extent of mutation/deletion ... Read More Background: Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are inherited X-linked disorders resulting from alterations in the dystrophin gene. Genotype-phenotype matching studies have revealed a link between disease severity, the amount of muscle dystrophin, and the extent of mutation/deletion on the dystrophin gene. This study aimed to assess the relationship between genetic alterations in the dystrophin gene and the clinical status of patients with dystrophinopathies among the Iranian population.Methods: This cross-sectional study examined 54 patients with muscle weakness caused by abnormalities in the dystrophin gene at a hospital affiliated to Isfahan University of Medical Sciences, Isfahan, Iran, in 2021. The participants’ demographic information, including age, family history of muscle dystrophies, and family history of other medical diseases as well as the type of muscular dystrophy were recorded. Furthermore, the number and region of deleted exons based on dystrophy types were also evaluated using multiplex ligation-dependent probe amplification (MLPA). The patients’ gaits were also assessed as using a wheelchair, the presence of waddling gaits, or toe gaits. The patients’ clinical status and the coexistence of pulmonary, bulbar, and mental conditions were also examined and compared between the two groups of dystrophinopathies.Results: In this study, 54 patients with dystrophinopathy with the mean age of 16.63 ± 12.10 years were evaluated, of whom 22 (40.7%) and 30 (55.6%) patients were classified as BMD and DMD, respectively. The most affected regions with deleted exons were exons 45-47 (n = 5) and 45-48 (n = 4) in patients with BMD, while exons 45, 48-52, 51-55, and 53 (2 cases per exon) were the most common affected exons in patients with DMD. Further analyses revealed that deletions in exons 45-47 and 51-55 were significantly associated with older and younger ages at the onset of becoming wheelchair-bound in patients with dystrophy, respectively. The hotspot range in both BMD and DMD was within exons 45-55 (n = 15 for each group); 63% of the patients had alterations on the dystrophin gene within this range [30 patients (68.18%) in the BMD group, 15 patients (53.57%) in the DMD group].Conclusion: Exon deletion was the most common genetic alteration in patients with dystrophinopathies. No significant difference was observed between DMD and BMD regarding the number of deleted exons. Deletions in exons 45-47 and 51-55 were linked to later and earlier onset of becoming wheelchair-bound, respectively.

Original Article

Chronic pain among Lebanese individuals with spinal cord injury: Pain interference and impact on quality of life

Nour El-Hoda Saleh; Sleiman Fneish; Ali Orabi; Ghadir Al-Amin; Ibrahim Naim; Zahra Sadek

Volume 22, Issue 4 , October 2023, Pages 238-248

https://doi.org/10.18502/cjn.v22i4.14529

Abstract

Background: Chronic pain is one of the most disabling consequences of spinal cord injury (SCI). Although studies have identified a link between chronic pain and decreased quality of life (QOL) among this population, few studies have looked into the experience of chronic pain in Lebanese individuals with ... Read More

Review Article

Olfactory dysfunction in patients with Parkinson's disease: A systematic review and meta-analysis

sara bagherieh; noor mohammad arefian; mahsa ghajarzadeh; arash tafreshinejad; alireza zali; omid mirmosayyeb; saeid safari

Volume 22, Issue 4 , October 2023, Pages 249-254

https://doi.org/10.18502/cjn.v22i4.14530

Abstract

Background: Parkinson’s disease (PD) is a progressive neuro-degenerative disease and olfactory dysfunction is considered as an important issue in these patients. The prevalence of olfactory dysfunction in patients with PD was reported variously in previous studies. Therefore, we designed this systematic ... Read More Background: Parkinson’s disease (PD) is a progressive neuro-degenerative disease and olfactory dysfunction is considered as an important issue in these patients. The prevalence of olfactory dysfunction in patients with PD was reported variously in previous studies. Therefore, we designed this systematic review and meta-analysis to estimate the pooled prevalence of olfactory dysfunction in patients with PD.Methods: Two expert researchers systematically searched PubMed, Scopus, EMBASE, Web of Science, Google Scholar, references of the papers, and conference abstracts. The titles and abstracts of the potential studies were evaluated after deleting the duplicates. We extracted data regarding the total number of participants, first author, publication year, the country of origin, mean age, mean disease duration, female/male, number with olfactory dysfunction, and name of the test. We evaluated the risk of potential bias by the Newcastle-Ottawa Quality Assessment Scale (adapted for cross-sectional studies). All statistical analyses were done using Stata software. To determine heterogeneity between the findings of included studies, inconsistency (I2) was calculated. We applied random effect model when I2 was more than 50%. P-value less than 0.05 was considered significant. Results: The literature search revealed 1546 studies; after deleting duplicates, 894 remained. Finally, twelve studies remained for meta-analysis. Studies were published between years of 2009 to 2021, the sample size of studies ranged between 30 and 2097, and the mean age ranged between 61 and 70 years. The pooled prevalence of olfactory dysfunction in patients with PD was estimated as 64% [95% confidence interval (CI): 44-84, I2 = 99.7%, P < 0.001]. The pooled prevalence of olfactory dysfunction using Sniffin's test was 67% (95% CI: 51-83) and using other tests was 60% (95% CI: 28-92).Conclusion: The results of this systematic review and meta-analysis showed that the pooled prevalence of olfactory dysfunction in patients with PD was 64% which should be considered by physicians.

Short Communication

Neuro-mucormycosis: Lessons from COVID-19-associated cases

Nahad Sedaghat; Masoud Etemadifar; Pouria Ghasemi; Mohammad Naghizadeh; Yousef Mokari; Mehri Salari; Bahar Golastani

Volume 22, Issue 4 , October 2023, Pages 255-260

https://doi.org/10.18502/cjn.v22i4.14531

Abstract

Background: Scarce data are available on the neurological presentations of coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) and COVID-19-unrelated rhino-orbito-cerebral mucormycosis (ROCM). This study aimed to compare the neurological presentations and their associated outcomes in patients ... Read More

Short Communication

Injudicious use of cranio-spinal imaging in Guillain-Barré syndrome in a low resource country

Muhammad Hassan; Mazhar Badshah; Mansoor Iqbal

Volume 22, Issue 4 , October 2023, Pages 261-264

https://doi.org/10.18502/cjn.v22i4.14532

Abstract

Background: Many patients being investigated for Guillain-Barré syndrome (GBS) undergo unnecessary neuroimaging. The objective of this study was to determine the proportion of patients with GBS undergoing neuroimaging investigation, and to investigate any association with different GBS variants ... Read More

Letter to the Editor

A case of type II fucosidosis-diagnosed with neuroradiological and dysmorphological findings

Sanjay M Khaladkar; Satvik Dhirawani; Aastha Agarwal; Vijetha Chanabasanavar; Tejvir Singh

Volume 22, Issue 4 , October 2023, Pages 265-267

https://doi.org/10.18502/cjn.v22i4.14534

Abstract

B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial

Shiva Nematgorgani; Soodeh Razeghi-Jahromi; Elham Jafari; Mansoureh Togha; Pegah Rafiee; Zeinab Ghorbani; Zeynab Sadat Ahmadi; Vali Baigi

Volume 21, Issue 2 , April 2022, , Pages 105-118

https://doi.org/10.18502/cjn.v21i2.10494

Abstract

Background: The B vitamins can potentially help prevent migraine. This study was designed to examine the effects of supplementation with thiamine (B1), pyridoxine (B6), cobalamin (B12), folic acid (B9), and a combination of these vitamins on women with episodic migraine (EM).Methods: This study was a ... Read More

Guillain-Barre syndrome in patients with coronavirus disease-2019: Report of six cases and review of literature

Ali Asghar Okhovat; Behnaz Ansari; Helia Hemasian; Bahram Haghi-Ashtiani; Soroor Advani; Bentolhoda Ziaadini; Siamak Abdi; Hajir Sikaroudi; Shahriar Nafissi; Farzad Fatehi

Volume 19, Issue 3 , July 2020, , Pages 122-130

https://doi.org/10.18502/cjn.v19i3.5425

Abstract

Background: Few studies have reported the association of Guillain-Barre syndrome (GBS) and coronavirus disease-2019 (COVID-19) infection. In this study, we reported GBS in six patients infected with COVID-19 and reviewed all existing literature about GBS in association with COVID-19. Methods: This study ... Read More

Assessment of computed tomography perfusion RAPID estimated core volume accuracy in patients following thrombectomy

Riwaj Bhagat; Allison Muha; Kerri Remmel; Wei Liu

Volume 21, Issue 1 , January 2022, , Pages 17-22

https://doi.org/10.18502/cjn.v21i1.9356

Abstract

Background: Computed Tomography Perfusion (CTP) maps ischemic core volume (CV) and penumbra following a stroke; however, its accuracy in early symptom onset is not well studied. We compared the accuracy of CTP RAPID estimated CV with diffusion weighted imaging (DWI) infarct volume (IV) in patients following ... Read More

Effect of energy conservation strategies on fatigue, function, and quality of life in adults with motor neuron disease: Randomized controlled trial

Hamid Reza Fateh; Reihaneh Askary-Kachoosangy; Niloofar Shirzad; Alireza Akbarzadeh-Baghban; Farzad Fatehi

Volume 21, Issue 2 , April 2022, , Pages 83-90

https://doi.org/10.18502/cjn.v21i2.10491

Abstract

Background: Fatigue is one of the most frequent complaints in patients with motor neuron diseases (MNDs), with a significant impact on the quality of life (QOL). Current pharmacological or non-pharmacological treatments of fatigue in this population lack enough evidence to be applied in the clinical ... Read More

A randomized controlled trial investigating the effects of a mediterranean-like diet in patients with multiple sclerosis-associated cognitive impairments and fatigue

Soodeh Razeghi-Jahromi; Rozita Doosti; Zeinab Ghorbani; Roghayyeh Saeedi; Maryam Abolhasani; Naeemeh Akbari; Fatemeh Cheraghi-Serkani; Abdorreza Naser Moghadasi; Amirreza Azimi; Mansoureh Togha; Mohammad Ali Sahraian

Volume 19, Issue 3 , July 2020, , Pages 112-121

https://doi.org/10.18502/cjn.v19i3.5424

Abstract

Background: Among multiple sclerosis (MS) related symptoms and complications, fatigue might impact roughly 90% of patients. Decline in cognitive function is one of the other complications that occur in the first years after disease onset. The Mediterranean diet is one of the well-known anti-inflammatory ... Read More Background: Among multiple sclerosis (MS) related symptoms and complications, fatigue might impact roughly 90% of patients. Decline in cognitive function is one of the other complications that occur in the first years after disease onset. The Mediterranean diet is one of the well-known anti-inflammatory dietary approaches. Therefore, this study aimed to explore the effects of a modified Mediterranean-like diet on cognitive changes and fatigue levels in comparison with a conventional standard diet over a 1-year follow-up. Methods: In the current single-blind randomized controlled trial, 34 MS patients in the Mediterranean- like diet group and 38 patients in the standard healthy diet group were studied for 1 year. The dietary interventions were modified each month by an expert nutritionist. MS-associated fatigue level was evaluated using the Modified Fatigue Impact Scale (MFIS). Cognitive assessment was also performed using Minimal Assessment of Cognitive Function in MS (MACFIMS). Results: Intergroup ‎comparisons demonstrated that after considering confounding variables in ANCOVA, fatigue scores appeared significantly lower in patients who were treated with the Mediterranean-like diet than those in the standard healthy diet group [Mean 95% confidence interval (CI)}: 33.93 (32.97-34.89) and 37.98 (36.99-38.97), respectively; P < 0.001]. However, the intergroup ‎analysis of cognitive status only showed a difference in the mean score of Brief Visuospatial Memory Test-Revised (BVMT-R) subtest of the MACFIMS. The BVMT-R‎ was higher among standard healthy diet patients compared to the Mediterranean-like diet group after the intervention following adjustment for covariates [Mean (95% CI): 23.73 (21.88-25.57) and 20.56 (18.60-22.51), respectively; P = 0.020]. Conclusion: In conclusion, the results of this study highlighted the higher protective effects of the Mediterranean-like diet against MS-related fatigue than the standard healthy diet. However, no significant improvement was observed in the cognitive status of MS patients after a 1-year treatment with the Mediterranean-like diet. More randomized clinical trials with larger sample sizes are needed to elucidate the effects of dietary modifications on MS-associated symptoms and complications.

Original Article

Isaacs’ syndrome: Clinical and paraclinical perspectives in a series of cases

Payam Sarraf; Mahan Shafie; Ghasem Farahmand; Mahsa Mayeli; Mojtaba Shahbazi; Hana Magrouni; Melika Jameie; Babak Ghelichnia Emrani; Maryam Rashidi-Jazani

Articles in Press, Accepted Manuscript, Available Online from 30 December 2023

Abstract

Background: Isaacs’ syndrome is a form of generalized peripheral nerve hyperexcitability (PNH) causing increased and continuous muscle activity characterized by muscle twitching, stiffness, cramps, myokymia, and pseudomyotonia. Herein, we aimed to review the clinical and paraclinical aspects of ... Read More

Original Article

Validity and reliability of the Iranian-developed version of the leisure questionnaire for people with multiple sclerosis: Psychometric properties

Seyed Mohammad Sadegh Hosseini; Mohsen Sarhady; Sahar Nurani-Gharaborghe

Articles in Press, Accepted Manuscript, Available Online from 31 December 2023

Abstract

Background: An effective and reliable assessment tool is essential for evaluating the leisure activities of patients. The purpose of this study is to assess the validity and reliability of the Iranian-developed version of leisure questionnaire for people with multiple sclerosis (MS).Methods: Psychometric ... Read More

Original Article

New diagnosis of multiple sclerosis in the setting of recent Sinopharm COVID-19 vaccine (BBIBP-CorV) exposure: A series of clinical cases and updated review of the literature

Sepideh Paybast; Melika Jameie; Mojtaba Shahbazi; Mohammad Amin Habibi; Seyed Ehsan Mohammadianinejad; Mohammad Hossein Harirchian

Articles in Press, Accepted Manuscript, Available Online from 08 January 2024

Abstract

Background: Multiple sclerosis (MS) is the most common cause of non-traumatic disability in young individuals. There are limited reports of developing demyelinating events following the coronavirus disease 2019 (COVID-19) vaccination.Methods: We reported all individuals (n = 8) with new MS diagnoses ... Read More

Original Article

Comparison of the effectiveness of modafinil and methylphenidate in treatment of excessive daytime sleepiness in patients with Parkinson’s disease

Ahmad Chitsaz; mohammad reza Najafi; Farzaneh Habibi; Sajad Amirhajloo

Articles in Press, Accepted Manuscript, Available Online from 10 January 2024

Abstract

Background: A large percentage of patients with Parkinson's disease (PD) suffer from excessive daytime sleepiness (EDS). This study aims to compare the effectiveness of modafinil and methylphenidate on EDS and side effects.Methods: Fifty nine patients with PD and EDS [Epworth Sleepiness Scale (ESS) more ... Read More

Original Article

Anticoagulation in the management of septic cavernous sinus thrombosis secondary to rhino-orbito-cerebral mucormycosis: A retrospective real-world experience

Kiana Amani; Mojtaba Shahbazi; Atefeh Behkar; Ghasem Farahmand; Shima Ghafouri; Sanaz Heydari; Maryam Kaeedi; Hana Magrouni; Fatemeh Alizadeh; Mojdeh Ghabaee; Payam Sarraf; Abbas Tafakhori; Hamed Amirifard; Sakineh Ranji-Burachaloo; Seyed Ehsan Mohammadianinejad; Melika Jameie; Mohammad Hossein Harirchian

Articles in Press, Accepted Manuscript, Available Online from 16 January 2024

Abstract

Background: COVID-19 was associated with an increased number of patients with mucormycosis (MCR), followed by septic cavernous sinus thrombosis (SCST). We evaluated the association between anticoagulation (AC) and mortality/morbidity of COVID-19-associated MCR (CAM)-induced SCST.Methods: In this retrospective ... Read More

Original Article

Psychometric validation of the Persian version of the CarerQol-7D instrument on caregivers of patients with multiple sclerosis

Hoda Faraji; Isa Akbarzadeh; Mehdi Yaseri; Mohammad Ali Sahraian; Shekoufeh Nikfar

Articles in Press, Accepted Manuscript, Available Online from 07 May 2024

Abstract

Background: Providing informal care can deeply influence, both physically and emotionally, the quality of life (QoL) of caregivers, especially when the disease becomes chronic. CarerQol-7D is one of the most common instruments for measuring informal care. We aimed to develop a Persian version of the ... Read More

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Original Article

A study on possible risk factors for progressive supranuclear palsy in southern part of India

Ancil George Thomas; Madhusudanan Mohan; Reji Thomas

Articles in Press, Accepted Manuscript, Available Online from 09 May 2024

Abstract

Background: The etiological factors leading to progressive supranuclear palsy (PSP) are poorly understood. This study aims to evaluate the role of various risk factors in patients with PSP.Methods: A case-control study was conducted over a period of two years from March 2016 to March 2018. The cases ... Read More

Letter to the Editor