Document Type: Special Articles

Authors

1 Department of Neurology, Neurosciences Research Center (NSRC), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Neurologist, Department of Neurology, Neurosciences Research Center (NSRC), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Department of Neurology, Neurosciences Research Center (NSRC), Student Research Committee, School of Medicine, Tabriz University of Medical Sciences, Imam Reza Hospital, Tabriz, Iran.

Abstract

Background: Due to underlying autoimmune background of Guillain-Barré syndrome (GBS), the possible role of infectious agents cytomegalovirus  (CMV) and  Epstein-Barr virus (EBV) and also due to association  of anti-ganglioside antibodies with GBS, the present study aimed to investigate the  associations   between serum anti-ganglioside antibodies (AGA) level,  type  of  infection  and electrodiagnostic (ED) findings with the severity and three- month functional outcome  of patients with GBS.Methods: In a prospective study, 30 patients with GBS were selected  and before starting the treatment, baseline serum samples of patients were obtained for measuring the serum AGA including  the  antibodies  against  GQ1b, GT1b, GD1a, GD1b, GM1, GM2, GM3 and strains of CMV and EBV. All the patients  were  precisely examined  for ED findings. Functional   status   of  patients on  admission and three months  after admission were recorded  according to the modified Rankin scale (mRS).Results: The  results of patients' serum  assessment revealed that CMV IgM was positive in one patient (3.3%), CMV IgG in 29 patients  (96.7%) and EBV IgG in 27 patients (90%). Anti-GM1 was found in 3 patients  (10%) and anti- GM3 was found only in one patient  (3.3%). However, no statistical significant association  was found  between the AGA and strain of the disease and ED findings.Conclusion: Despite the coexistence  of AGA and serum antibodies  against  CMV and  EBV in some GBS patients, there  was not clear association  in this regard. However, the  AGA was  positive  in  patients   who  suffered  from severe phase of the disease.