Document Type: Special Articles

Authors

1 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

2 Department of Neurology AND Iranian Center of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

3 Department of Neurology AND Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

4 Department of Neurology, Sina MS Research Center, Tehran University of Medical Sciences, Tehran, Iran.

5 Department of Community Nutrition, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background:  The  role of nutrition  in the  progression  of multiple  sclerosis (MS) and  related  complications  such  as fatigue  has been  reported by several studies.  The  aim of this  study  is the  assessment of nutritional  status  and  its relationship with fatigue in multiple sclerosis patients.Methods:  This  is  a  cross-sectional study, in which  101 relapsing-remitting MS patients  were enrolled.The fatigue status  was determined using the validated  Persian version of the  Modified  Fatigue Impact  Scale (MFIS). Dietary intake was assessed using  a  3-day  food  record questionnaire  and  compared  to  dietary  reference  intake (DRI)  values.  Association  between variables  was determined using Pearson Correlation Coefficient.Results:  In  the  preset  study,  25  men  and  76  women (total  =  101)  were  enrolled.  Analysis of  dietary  intake showed  that daily intake of vitamin D, folate, calcium, and magnesium  were  significantly  lower  than  DRI  in  all  of patients.  In  men,  zinc intake  was significantly lower than DRI;  while, in women, iron was significantly below  the DRI level. After adjusting for energy, MFIS and its physical subscale were highly correlated with intake of folate and magnesium.Conclusion: Our findings support that lower magnesium and folate diets are correlated with higher fatigue scores in MS patients.