Document Type: Special Articles

Authors

1 Associate Professor, Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.

2 Community and Preventive Medicine Specialist, Iran University of Medical Sciences, Tehran, Iran

3 Assistant Professor, Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran

4 Assistant Professor, Department of Neurology, Iran University of Medical Sciences, Tehran, Iran

5 Professor, Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract

Background: Health assessment in patients  with epilepsy (PWE) should  include  both  clinical outcomes and  health related quality of life (HRQOL) measures. The quality of life (QoL) in epilepsy-31 inventory  (QOLIE-31) is widely used for QOL studies  in epilepsy. This study  aims to evaluate psychometrics  of the Persian version of the inventory (QOLIE-31-P).Methods:  Following a  standard  forward-backward translation  and cultural adaptation, the construct  validity of the QOLIE-31-P  was  assessed  by  explanatory factor analysis, multi-trait  scaling  analysis, and  known group comparison. The criterion validity  was   assessed   by calculating   the   Pearson   correlation   to  SF-36 (36-item short-form health  survey). The reliability was assessed  by calculating Cronbach’s alpha and test-retest study.Results: The  factor analysis  extracted   from  8  factors explaining  70.35%  of  the  variations. Item-scale correlations  revealed  that  individual items  significantly had  the strongest  association  with  the  domain   they were  loaded on. The Pearson  coefficient  of correlation between QOLIE-31-P and the overall scores of SF-36 was 0.876  (P <  0.0001).  Patient  with  medically  controlled seizures  scored  higher than  those  who  experienced seizures   during the  previous year  to  study  date (P <  0.0001).  The Cronbach’s  α  of  overall  QOLIE-31-P inventory  was 0.9. The overall test-retest coefficient  of correlation was 0.68 (P = 0.003).Conclusion: QOLIE-31-P is a valid and reliable tool to be applied in health assessment of patients with epilepsy.