1. Environmental risk factors of multiple sclerosis in the Middle East and North Africa region: A systematic review

Hossein Maroufi; Seyyed Hosein Mortazavi; Mohammad Ali Sahraian; Sharareh Eskandarieh

Articles in Press, Accepted Manuscript, Available Online from 21 August 2021

  Background: The environmental factors play a role as risk factors of multiple sclerosis (MS). This study aimed at gathering environmental risk factors of MS in the Middle East and North Africa (MENA). Methods: We used MEDLINE and EMBASE databases by a systematic review method. Out of a total of 123 studies, ...  Read More

3. Cost-effectiveness of ocrelizumab for treatment of Iranian patients with relapsing multiple sclerosis

Nayyereh Ayati; Saeed Taheri; Mohammad Ali Sahraian; Shekoufeh Nikfar

Articles in Press, Accepted Manuscript, Available Online from 24 July 2021

  Background: The current study desired to conduct an economic analysis on ocrelizumab (OCR), a new relapsing multiple sclerosis (RMS) treatment strategy, in comparison to natalizumab (NTL), as one of the mostly-used disease-modifying therapies (DMTs) in Iran. Methods: A 31-health-state Markov model, based ...  Read More

4. Whole grains and legumes consumption in association with neuromyelitis optica spectrum disorder odds

Nasim Rezaeimanesh; Shadi Ariyanfar; Mohammad Ali Sahraian; Abdorreza Naser Moghadasi; Zeinab Ghorbani; Soodeh Razegh-Jahromi

Articles in Press, Accepted Manuscript, Available Online from 31 July 2021

  Background: The environmental risk factors of neuromyelitis optica spectrum disorder (NMOSD) are not fully specified.Regarding the evidence on the possible protective effects of whole grains and legumes against inflammatory disorders, we examined the association between the mentioned dietary components ...  Read More

5. Medical history risk factors in primary progressive multiple sclerosis: A case-control study

Hossein Maroufi; Abdorreza Naser Moghadasi; Hossein Rezaei-Aliabadi; Mohammad Ali Sahraian; Sharareh Eskandarieh

Volume 20, Issue 2 , Spring 2021, , Pages 86-94


  Background: The association betweenmedical history and primary progressive multiple sclerosis (PPMS) development has not been well documented in the pertinent literature.The possible association between 23 medical diseases and PPMS occurrence was assessed in the present study. Methods: In order to figure ...  Read More

6. Economic sanctions against Iran as an important factor in threatening the health of patients with multiple sclerosis

Mohammad Ali Sahraian; Abdorreza Naser Moghadasi; Sharareh Eskandarieh

Volume 20, Issue 1 , Winter 2021, , Pages 15-22


  Background: After intensified economic sanctions against Iran, decreased welfare of patients were more recognizable. The present study was aimed at identifying the challenges and stress level experienced by patients with multiple sclerosis (MS) regarding treatment and health care services in 2018-2019 ...  Read More

7. Impact of supplementation with "multivitamin-mineral" specially formulated to improve fatigue and inflammatory state in patients with multiple sclerosis: A triple-blind, randomized, placebo-controlled trial

Sama Bitarafan; Elmira Karimi; Abdorreza Naser Moghadasi; Razieh Sadat Kazemi-Mozdabadi; Zinat Mohammadpour; Mohammad Ali Sahraian

Volume 19, Issue 4 , Autumn 2020, , Pages 180-189


  Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with the most common complaint of fatigue. A high number of patients with MS are interested in taking dietary supplements as a complementary therapy. We propose a specially formulated supplement for patients ...  Read More

8. A randomized controlled trial investigating the effects of a mediterranean-like diet in patients with multiple sclerosis-associated cognitive impairments and fatigue

Soodeh Razeghi-Jahromi; Rozita Doosti; Zeinab Ghorbani; Roghayyeh Saeedi; Maryam Abolhasani; Naeemeh Akbari; Fatemeh Cheraghi-Serkani; Abdorreza Naser Moghadasi; Amirreza Azimi; Mansoureh Togha; Mohammad Ali Sahraian

Volume 19, Issue 3 , Summer 2020, , Pages 112-121


  Background: Among multiple sclerosis (MS) related symptoms and complications, fatigue might impact roughly 90% of patients. Decline in cognitive function is one of the other complications that occur in the first years after disease onset. The Mediterranean diet is one of the well-known anti-inflammatory ...  Read More

9. Association of cigarette smoking with neuromyelitis optica-immunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder

Sharareh Eskandarieh; Abdorreza Naser Moghadasi; Mohammad Ali Sahraian; Amir Reza Azimi; Negar Molazadeh

Volume 18, Issue 3 , Summer 2019, , Pages 93-98

  Background: Neuromyelitis optica spectrum disorder (NMOSD) is a neuroinflammatory demyelinating disease caused by the presence of a highly specific serum autoantibody marker, NMO-immunoglobulin G (NMO-IgG), that reacts against the water channel aquaporin-4 (AQP4). The present study examined the association ...  Read More

10. Induction or aggravation of other immune-mediated disorders by disease-modifying therapy in treatment of multiple sclerosis

Seyed Mohammad Baghbanian; Mohammad Ali Sahraian

Volume 17, Issue 3 , Summer 2018, , Pages 129-136

  Interferon beta (IFN-β) and glatiramer acetate (GA) are the primary therapeutic immunomodulatory agents that interfere with relapsing-remitting multiple sclerosis (RRMS), and the most commonly-used drugs as well. Induction or aggravation of other immune-mediated diseases has been reported following ...  Read More

11. Pegylated versus non-pegylated interferon beta 1a in patients with relapsing-remitting multiple sclerosis: A cost-effectiveness analysis

Amir Hashemi-Meshkini; Hedieh Sadat Zekri; Hasan Karimi-Yazdi; Pardis Zaboli; MohammadAli Sahraian; Shekoufeh Nikfar

Volume 17, Issue 3 , Summer 2018, , Pages 123-128

  Background: Pegylated (PEG) interferon beta 1a has been approved by the United States Food and Drug Administration (USFDA) as an alternative to interferon beta 1a for multiple sclerosis (MS). Due to its higher price, this study aimed to evaluate the cost-effectiveness of PEG-interferon beta 1-a compared ...  Read More

12. Evaluating the relationship between emotional intelligence and cognitive disorders in patients with Multiple Sclerosis

Mahsa Owji; Mohammad Ali Sahraian; Maryam Bidadian; Fereshteh Ghadiri; Farnaz Etesam; Amirreza Azimi; Abdorreza Naser Moghadasi

Volume 17, Issue 2 , Spring 2018, , Pages 78-81

  Background: Emotional intelligence refers to a process through which an individual is not only capable of understanding his/her/others’ emotions, but also is able to manage them. Emotional intelligence can get disturbed due to different neurological diseases. Since cognition and emotion are directly ...  Read More

13. Recurrent isolated optic neuritis: A study on 22 patients

Mahsa Arzani; Mohammad Ali Sahraian; Hamed Rezaei; Abdorreza Naser-Moghadasi

Volume 16, Issue 3 , Summer 2017, , Pages 130-135

  Background: Isolated relapsing optic neuropathy is a recurrent painful optic nerve inflammation without any sign of other demyelinating diseases such as multiple sclerosis (MS) or neuromyelitis optica (NMO) spectrum disorders, and the attacks are purely responsive to steroid therapy.Methods: Recurrent ...  Read More

15. Comparison of serum vitamin D level in multiple sclerosis patients, their siblings, and healthy controls.

Ghazaleh Eskandari; Mahsa Ghajarzadeh; Mir Saeed Yekaninejad; Mohammad Ali Sahraian; Razieh Gorji; Faezeh Rajaei; Abbas Norouzi-Javidan; Alireza Faridar; Amirreza Azimi

Volume 14, Issue 2 , Spring 2015, , Pages 81-85

  Background: Multiple sclerosis (MS) is an autoimmune,  neuro- inflammatory disease  of  central nervous system affecting physical, emotional, and cognitive aspects of patients. Association of vitamin D deficiency and MS has been shown in previous studies. The aim of this study was to evaluate serum ...  Read More

16. Vitamin D and multiple sclerosis.

Asghar Amini Harandi; Ali Amini Harandi; Hossein Pakdaman; Mohammad Ali Sahraian

Volume 13, Issue 1 , Winter 2014, , Pages 1-6

  Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune ...  Read More

17. Level of attitude toward complementary and alternative medicine among Iranian patients with multiple sclerosis.

Mohammad Hossein Harirchian; Mohammad Ali Sahraian; Amir Hosseinkhani; Nasibeh Amirzargar

Volume 13, Issue 1 , Winter 2014, , Pages 13-18

  Background: Multiple sclerosis (MS) is an unpredictable neurological disease leading to severe disability in young adults.  The  majority of MS patients  use  complementary and     alternative medicine  (CAM)  as adjunct  to conventional  therapies.  This study  aimed  to  investigate ...  Read More

18. Epidemiology of multiple sclerosis in Qom: Demographic study in Iran.

Saeed Rezaali; Ahad Khalilnezhad; Abdorreza Naser Moghadasi; Samira Chaibakhsh; Mohammad Ali Sahraian

Volume 12, Issue 4 , Autumn 2013, , Pages 136-143

  Background: Recent studies have demonstrated controversial results and somewhat increased frequency of multiple  sclerosis  (MS). We reevaluated  the  files of  MS patients  from Qom Province of Iran in order to investigate the epidemiology of the disease.Methods:  Demographic   and  clinical ...  Read More

19. Clinical and demographic factors affecting disease severity in patients with multiple sclerosis.

Somayeh Baghizadeh; Mohammad Ali Sahraian; Nahid Beladimoghadam

Volume 12, Issue 1 , Winter 2013, , Pages 1-8

  Background: The clinical course of multiple sclerosis (MS) evolves over many years. Its prognosis is highly variable among affected individuals, i.e. while some suffer from early severe disabilities, others remain ambulatory and functional for many years. We used Multiple Sclerosis Severity Score (MSSS) ...  Read More

21. Perceived impact of epilepsy in teaching hospitals of Tehran University.

Mahmoud Motamedi; Mohammad Ali Sahraian; Sasan Moshirzadeh

Volume 10, 3-4 , Autumn 2011, , Pages 43-5

  Background: Epileptic seizures would result in embarrassment in society and have some negative impact on the patients' social activities. The aim of this study was to show the perceived impact of epilepsy by patients on different aspect of their social activities including occupation, marriage and education.Methods: ...  Read More