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Iranian journal of neurology Iranian journal of neurology

Volume 17, Issue 1 , January 2018

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Iranian journal of neurology Iranian journal of neurology

Volume 16, Issue 4 , October 2017

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  Journal IndexOfficial journal of Iranian Neurological Association  Read More Journal IndexOfficial journal of Iranian Neurological Association

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Iranian journal of neurology Iranian journal of neurology

Volume 16, Issue 3 , July 2017

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  Journal IndexOfficial journal of Iranian Neurological Association  Read More Journal IndexOfficial journal of Iranian Neurological Association

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Iranian journal of neurology Iranian journal of neurology

Volume 16, Issue 2 , April 2017

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  Iranian journal of neurology Iranian journal of neurology  Read More Iranian journal of neurology Iranian journal of neurology

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Iranian journal of neurology Iranian journal of neurology

Volume 16, Issue 1 , January 2017

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  Official journal of Iranian Neurological Association  Read More Official journal of Iranian Neurological Association

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Iranian journal of neurology Iranian journal of neurology

Volume 15, Issue 4 , October 2016

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  ORCID iDs can only be assigned by . You must conform to their standards for expressing ORCID iDs, and include the full URI  Read More ORCID iDs can only be assigned by . You must conform to their standards for expressing ORCID iDs, and include the full URI

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Iranian journal of neurology Iranian journal of neurology

Volume 15, Issue 3 , August 2016

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  Official journal of Iranian Neurological Association  Read More Official journal of Iranian Neurological Association

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Iranian journal of neurology Iranian journal of neurology

Volume 15, Issue 2 , April 2016

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  Clck to download the index of this issue.No Astract##  Read More Clck to download the index of this issue.No Astract##

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Iranian joiurnal of neurology Iranian joiurnal of neurology

Volume 15, Issue 1 , January 2016

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  Click to download the index of this issue.  Read More Click to download the index of this issue.

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Iranian Journal of Neurology Iranian Journal of Neurology

Volume 14, Issue 4 , October 2015, , Pages 1-1

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  Click to download the index of this issue.    Read More Click to download the index of this issue.  

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Iranian Journal of Neurology Iranian Journal of Neurology

Volume 14, Issue 3 , July 2015, , Pages 1-1

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  Click to download the index of this issue.   Read More Click to download the index of this issue. 

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Iranian Journal of Neurology Iranian Journal of Neurology

Volume 14, Issue 2 , June 2015, , Pages 1-1

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Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazole-induced seizures in rats.

Reza Karami; Mahmoud Hosseini; Toktam Mohammadpour; Ahmad Ghorbani; Hamid Reza Sadeghnia; Hassan Rakhshandeh; Farzaneh Vafaee; Mahdi Esmaeilizadeh

Volume 14, Issue 2 , June 2015, , Pages 59-66

Abstract

  Background: An important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. Coriandrum sativum has been shown that have antioxidant effects. Central nervous system depressant effects of C. sativum have also been reported. In this study, the effects of hydroalcoholic ...  Read More Background: An important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. Coriandrum sativum has been shown that have antioxidant effects. Central nervous system depressant effects of C. sativum have also been reported. In this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following seizures induced by pentylenetetrazole (PTZ) was investigated in rats.Methods: The rats were divided into five groups and treated: (1) Control (saline), (2) PTZ (90 mg/kg, i.p.), (3-5) three doses (100, 500 and 1000 mg/kg of C. sativum extract (CSE) before PTZ. Latencies to the first minimal clonic seizures (MCS) and the first generalized tonic-clonic seizures (GTCS) were recorded. The  cortical and hippocampal tissues were then removed for biochemical measurements.Results: The extract significantly increased the MCS and GTCS latencies (P < 0.01, P < 0.001) following PTZ-induced seizures. The malondialdehyde (MDA) levels in both cortical and hippocampal tissues of PTZ group were significantly higher than those of the control animals (P < 0.001). Pretreatment with the extract prevented elevation of the MDA levels (P < 0.010–P < 0.001). Following PTZ administration, a significant reduction in total thiol groups was observed in both cortical and hippocampal tissues (P < 0.050). Pretreatment with the 500 mg/kg of the extract caused a significant prevention of decreased in total thiol concentration in the cortical tissues (P < 0.010).Conclusion: The present study showed that the hydroalcoholic extract of the aerial parts of C. sativum possess significant antioxidant and anticonvulsant activities.

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Efficacy of high-dose vitamin D3 supplementation in vitamin D deficient pregnant women with multiple sclerosis: Preliminary findings of a randomized-controlled trial.

Masoud Etemadifar; Mohsen Janghorbani

Volume 14, Issue 2 , June 2015, , Pages 67-73

Abstract

  Background: The aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin D3 supplementation during pregnancy in women with multiple sclerosis (MS) in Isfahan, Iran.Methods:In a single center open-label randomized, controlled clinical Phase I/II pilot study, 15 pregnant ...  Read More Background: The aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin D3 supplementation during pregnancy in women with multiple sclerosis (MS) in Isfahan, Iran.Methods:In a single center open-label randomized, controlled clinical Phase I/II pilot study, 15 pregnant women with confirmed MS with low serum 25-hydroxyvitamin D (25(OH)D) levels were randomly allocated to receive either 50,000 IU/week vitamin D3 or routine care from 12 to 16 weeks of gestation till delivery. The main outcome measures were mean change in serum 25(OH)D levels, expanded disability status scale (EDSS) score, and number of relapse events during pregnancy and within 6 months after delivery.Results: Average serum 25(OH)D level at the end of trial in vitamin D3 supplemented group was higher than routine care group (33.7 ng/mL vs. 14.6 ng/ml, P < 0.050). In vitamin D3 group, the mean EDSS did not changed 6 months after delivery (P > 0.050), whereas in routine care group, the mean EDSS increased from 1.3 (0.4) to 1.7 (0.6) (P < 0.070). Women in vitamin D3 group appeared to have fewer relapse events during pregnancy and within 6 months after delivery. No significant adverse events occurred.Conclusion:Adding high dose vitamin D3 supplementation during pregnancy to routine care of women with MS had significant effect on the serum 25(OH)D levels, EDSS and number of relapse events during pregnancy and within 6 months after delivery.

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Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran.

Omid Sadeghi; Morteza Nasiri; Zahra Maghsoudi; Naseh Pahlavani; Masoud Rezaie; Gholamreza Askari

Volume 14, Issue 2 , June 2015, , Pages 74-80

Abstract

  Background:Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of pyridoxine  ...  Read More Background:Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of pyridoxine  supplementation on severity, frequency and duration of migraine attacks as well as headache diary results (HDR).Methods:This double-blind randomized clinical trial study was conducted on 66 patients with migraine with aura (MA) in Khorshid and Emam Mosa Sadr clinics of Isfahan University of Medical Sciences, Iran, in 2013. Patients were randomly allocated to receive either pyridoxine supplements (80 mg pyridoxine per day) or placebo. Severity, frequency and duration of migraine attacks and HDR were measured at baseline and at the end of the study.Results:Mean age of patients was 34.24 ± 9.44 years old. Pyridoxine supplementation led to a significant decrease in headache severity (-2.20 ± 1.70 compared with -1 ± 1.50; P = 0.007), attacks duration (-8.30 ± 12.60 compared with -1.70 ± 9.60; P = 0.030) and HDR (-89.70 ± 134.60 compared with -6.10 ± 155.50; P = 0.040) compared with placebo, but was not effective on the frequency of migraine attacks (-2.30 ± 4 compared with -1.20 ± 7.80; P = 0.510).Conclusion:Pyridoxine supplementation in patients with MA was effective on headache severity, attacks duration and HDR, but did not affect the frequency of migraine attacks.

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Comparison of serum vitamin D level in multiple sclerosis patients, their siblings, and healthy controls.

Ghazaleh Eskandari; Mahsa Ghajarzadeh; Mir Saeed Yekaninejad; Mohammad Ali Sahraian; Razieh Gorji; Faezeh Rajaei; Abbas Norouzi-Javidan; Alireza Faridar; Amirreza Azimi

Volume 14, Issue 2 , June 2015, , Pages 81-85

Abstract

  Background: Multiple sclerosis (MS) is an autoimmune,  neuro- inflammatory disease  of  central nervous system affecting physical, emotional, and cognitive aspects of patients. Association of vitamin D deficiency and MS has been shown in previous studies. The aim of this study was to evaluate serum ...  Read More Background: Multiple sclerosis (MS) is an autoimmune,  neuro- inflammatory disease  of  central nervous system affecting physical, emotional, and cognitive aspects of patients. Association of vitamin D deficiency and MS has been shown in previous studies. The aim of this study was to evaluate serum vitamin D level in MS cases and their sex-matched healthy siblings (who are genetically near similar) and non-relative sex-matched healthy controls.Methods: A total of 135 subjects enrolled in this case- control study. Group one (n = 45) consisted of patients with established MS. Group two (n = 45) included sex- matched healthy siblings of the group one and group three participants (n = 45) were non-relative sex- matched  healthy  controls.  Demographic  data  (age, sex), level of education, daily sun exposure duration, and month of birth gathered for all. Serum sample of all participants was collected for 25-hydroxy vitamin D measurement.Results: There was no significant difference between vitamin D level, sun exposure duration, education level, and season of birth in three evaluated groups. Mean vitamin D level was 8.2 ± 10.1 (nmol/l) in women and 13.3 ± 7 (nmol/l) in men (P = 0.001). There was a significant positive correlation between daily sun exposure duration and vitamin D level in whole participants (r = 0.28, P < 0.001) as well as in MS patients (r = 0.32, P = 0.030). Mean vitamin D level was significantly lower  in  participants  who  have  born  in spring and summer.Conclusion:  Vitamin  D  deficiency  is  high  among Iranian population as well as MS patients.

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Comparison of frequencies of non motor symptoms in Indian Parkinson's disease patients on medical management versus deep brain stimulation: A case-control study.

Kandadai Rukmini Mridula; Rupam Borgohain; Shaik Afshan Jabeen; Gaddamanugu Padmaja; Vcs Srinivasarao Bandaru; Praveen Ankathi; Meena A Kanikannan; Mohammed Shujath Ali Khan

Volume 14, Issue 2 , June 2015, , Pages 86-93

Abstract

  Background: Non motor symptoms (NMS) of idiopathic Parkinson’s disease (PD) are a major cause of disability and recognition of these symptoms and treatment is important for comprehensive health care. Deep   brain   stimulation   of   bilateral   subthalamic nucleus deep brain stimulation ...  Read More Background: Non motor symptoms (NMS) of idiopathic Parkinson’s disease (PD) are a major cause of disability and recognition of these symptoms and treatment is important for comprehensive health care. Deep   brain   stimulation   of   bilateral   subthalamic nucleus deep brain stimulation (STN DBS) has been shown to improve motor symptoms in PD and effects on NMS are unknown. To investigate the NMS among PD patients who underwent STN DBS.Methods: We recruited prospectively 56 patients with PD, who had undergone bilateral STN DBS and 53 age and duration of illness  matched PD patients on dopaminergic therapy (controls). NMS were assessed using 30 item questionnaire NMS Quest. These questions  evaluated  9 domains, gastrointestinal, urinary,  cardiovascular, sexual, cognition (apathy/attention/memory), anxiety/depression, hallucinations/delusions, sleep an dmiscellaneous. Comparison was done on individual symptoms as well as  in  various  domains.  This  study  was  carried  at Nizam’s  Institution  of  Medical  Sciences  and  study period was from January 2011 to December 2012. Results:  Patients  who underwent STN  DBS  had  a significantly lower  mean  total  score  on  NMS  quest (6.7   ±   3.8)   compared   to   controls   (8.4   ±   3.7) (P   <   0.00100).  Symptoms   in   the   domains   of cardiovascular, gastrointestinal, sleep were significantly less    frequent  while  sexual  disturbances  were significantly more frequent among patients compared to controls.  On  individual  symptom  analysis,  nocturia (P  <  0.00010),  unexplained  pains  (P  <  0.00010), nausea  and  vomiting,  constipation,  lightheadedness, depression, and insomnia were less prevalent, while sexual disturbances were significantly more common in STN DBS group compared to controls.Conclusion: Bilateral STN DBS not only improves the motor symptoms but also improves many NMS in PD patients.

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Stroke specific quality of life questionnaire: Test of reliability and validity of the Persian version.

Mojtaba Mahmoodi; Anahid Safari; Mehrdad Vossoughi; Fatemeh Golbon-Haghighi; Maliheh Kamali-Sarvestani; Haleh Ghaem; Afshin Borhani-Haghighi

Volume 14, Issue 2 , June 2015, , Pages 94-100

Abstract

  Background: The aim was to assess the reliability and the validity of the translated version of the stroke specific quality of life (SS-QOL) questionnaire in Iranian post-stroke patients.Methods: This project was performed at the Shiraz University of Medical Sciences, Shiraz, Iran, between 12  April  ...  Read More Background: The aim was to assess the reliability and the validity of the translated version of the stroke specific quality of life (SS-QOL) questionnaire in Iranian post-stroke patients.Methods: This project was performed at the Shiraz University of Medical Sciences, Shiraz, Iran, between 12  April  2010  and  24  February 2011.  The  English version of the SS-QOL was translated into Persian by “forward-backward” translation, cognitive inquiring and cultural adaptation process. The reliability and internal consistency were measured by Cronbach’s alpha coefficient. Validity was assessed using convergent and divergent validity through Spearman’s correlation coefficient.Results: Our study included 117 post-stroke patients, consisting of 57 (48.7%) men and 60 (51.3%) women. The mean age of the patients was 81.60 ± 7.52 (range 60-88) years. The Persian version of the SS-QOL proved reliable (Cronbach’s α = 0.96). Internal consistency was excellent for both demographic and patients’ clinical characteristics (Cronbach’s α ≥ 0.70). The scaling success rates were 100% for convergent validity of each scale. Divergent validity for all 12 scales was considered acceptable, whereas each scale had a 100% scaling success rate for convergent validity.Conclusion: The Persian version of SS-QOL should be mentioned as a noteworthy instrument to specify different  aspects  of  health  related  QOL  of  patients suffering stroke and hence that clinicians, researchers and epidemiologist can exploit it trustfully.

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Development, cross-cultural adaptation, and validation of the Persian Mississippi Aphasia Screening Test in patients with post-stroke aphasia.

Ahmad Reza Khatoonabadi; Noureddin Nakhostin-Ansari; Amin Piran; Hamid Tahmasian

Volume 14, Issue 2 , June 2015, , Pages 101-107

Abstract

  Background:  The  Mississippi  Aphasia  Screening Test (MAST) is a brief screening test for assessing the expressive and receptive language abilities in patients with  aphasia.  The  objective  of  the  study  was  to develop and validate the Persian version of the MAST (MASTp) as a screening ...  Read More Background:  The  Mississippi  Aphasia  Screening Test (MAST) is a brief screening test for assessing the expressive and receptive language abilities in patients with  aphasia.  The  objective  of  the  study  was  to develop and validate the Persian version of the MAST (MASTp) as a screening test for language disorders in patients with post-stroke aphasia.Methods: This study used a cross-sectional design to cross- culturally   adapt   the   MASTp   following   the guidelines for the process of cross-cultural adaptation of measures. A total of 40 subjects (20 patients with post-stroke aphasia  and  20  healthy subjects)  were included. The MASTp was tested for floor or ceiling effects,   internal   consistency   reliability,   intra-rater reliability, discriminative validity, and factor structure.Results:  There  were  no  floor  or  ceiling  effects  for MASTp  total  score.  The  MASTp  yielded  values  for internal consistency reliability that were not adequate (Cronbach’s alpha 0.64 and 0.66 for test and retest, respectively. The  intra-rater reliability of  the  MASTp within a 7 day-interval was excellent for total score (ICC agreement =  0.96) and  both  expressive  index (ICC = 0.95) and receptive index (ICC agreement = 0.98). here were statistically  ignificant differences in MASTp total scores and both indexes between patients and healthy subjects suggesting the discriminative validity of the MASTp (P < 0.001). Factor analysis revealed a 3- factor solution, which jointly accounted for 72.06% of the total variance. Additional factor analysis suggested 6-item MASTp as a unidimensional measure.Conclusion:  The  MASTp  is  useful  as  a  valid  and reliable screening tool for evaluation of language abilities in Persian speaking patients with aphasia after stroke.

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Unilateral cortical hyperintensity in diffusion-weighted MRI; New criteria for early sporadic Creutzfeldt-Jakob disease.

Nasim Tabrizi; Mahmoud Abedini

Volume 14, Issue 2 , June 2015, , Pages 108-109

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Cyclic headaches in β-thalassemia intermedia case presenting as moyamoya syndrome.

Süha Akpınar; Güliz Yılmaz; Emre Çelebioğlu

Volume 14, Issue 2 , June 2015, , Pages 110-112

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Intracranial hypertension and cerebellar symptoms due to Lhermitte-Duclos disease.

Farhad Assarzadegan; Atoosa Gharib; Shirin Behbahani; Meysam Ebrahimi-Abyaneh

Volume 14, Issue 2 , June 2015, , Pages 113-115

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Coexistence of Ehlers-Danlos syndrome and multiple sclerosis.

Hatice Kose Ozlece; Faik Ilik; Nergiz Huseyinoglu

Volume 14, Issue 2 , June 2015, , Pages 116-117

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Epileptic syndromes: From clinic to genetic.

Abbas Tafakhori; Vajiheh Aghamollaii; Sara Faghihi-Kashani; Payam Sarraf; Laleh Habibi

Volume 14, Issue 1 , March 2015, , Pages 1-7

Abstract

  Epilepsy is one of the most common neurological disorders. Studies have demonstrated that genetic factors have a strong role in etiology of epilepsy. Mutations in genes encoding ion channels, neurotransmitters and other proteins involved in the neuronal biology have been recognized in different types ...  Read More Epilepsy is one of the most common neurological disorders. Studies have demonstrated that genetic factors have a strong role in etiology of epilepsy. Mutations in genes encoding ion channels, neurotransmitters and other proteins involved in the neuronal biology have been recognized in different types of this disease. Moreover, some chromosomal aberration including ring chromosomes will result in epilepsy. In this review, we intend to highlight the role of molecular genetic in etiology of epilepsy syndromes, inspect the most recent classification of International League against Epilepsy and discuss the role of genetic counseling and genetic testing in management of epilepsy syndromes. Furthermore, we emphasize on collaboration of neurologists and geneticists to improve diagnosis and management.

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Iranian Journal of Neurology Iranian Journal of Neurology

Volume 14, Issue 1 , March 2015, , Pages 1-1

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