Hamidreza Hatamian; Alia Saberi; Matin Pourghasem
Volume 13, Issue 4 , Autumn 2014, , Pages 237-240
Abstract
Background: Several factors influence on the outcome of ischemic stroke. The aim of this study was determination the relationship between stroke mortality and red blood cell parameters.Methods: This cross-sectional study was conducted from 2011 July to June 2012. For all patients with ischemic ...
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Background: Several factors influence on the outcome of ischemic stroke. The aim of this study was determination the relationship between stroke mortality and red blood cell parameters.Methods: This cross-sectional study was conducted from 2011 July to June 2012. For all patients with ischemic stroke in middle cerebral artery (MCA) territory, the cell blood count test was performed. We recorded their mortality on the 1st week and the 1st month after ischemic stroke. Data analysis was performed using t-test, χ2, Mann–Whitney U- test, logistic regression and receiver operating characteristic curve in SPSS for Windows 19.0.Results: A total of 98 subjects (45.9% men and 54.1% women) with the mean age of 71.0 ± 13.9 years were assessed, while 67.3% of them were anemic. The prevalence of 1st week mortality among anemic and non- anemic patients was 40.9% and 34.4% (P = 0.534). The prevalence of mortality after 1st week till 1st month was 19.6% and 21.0% respectively (P = 0.636). In univariant analysis, only 1st month mortality had a significant relationship with red blood cell (RBC) count (P = 0.022). However, the result of logistic regression model showed that RBC (P = 0.012) and mean corpuscular volume (MCV) (P = 0.021) remained as predictors of the 1st week and the 1st month mortality (P = 0.011 and P = 0.090 respectively). The best cutoB point of RBC for the prediction of the 1st week mortality with 44.7% speciCcity and 69.5% sensitivity was estimated 4.07 million/μl and for the 1st month mortality with 46.6% speciCcity and 72.2% sensitivity was estimated 4.16 million/μl.Conclusion: The RBC count and MCV are independent predictors of ischemic stroke short-term mortality.
Hooshang Gerami; Alia Saberi; Shadman Nemati; Ehsan Kazemnejad; Mohammad Aghajanpour
Volume 11, Issue 3 , Summer 2012, , Pages 106-110
Abstract
Background: It is still a challenge to find an effective treatment for tinnitus. The aim of this study was the evaluation of carbamazepine and oxcarbazepine effects on tinnitus.Methods:In a randomized double-blind clinical trial, 57 patients who were visited in a university hospital due to chronic non-pulsatile ...
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Background: It is still a challenge to find an effective treatment for tinnitus. The aim of this study was the evaluation of carbamazepine and oxcarbazepine effects on tinnitus.Methods:In a randomized double-blind clinical trial, 57 patients who were visited in a university hospital due to chronic non-pulsatile tinnitus, were randomized in three groups and treated with carbamazepine (300-600 mg/day), oxcarbazepine (450-900 mg/day) and placebo for 12 weeks. Visual analogue scale (VAS) and tinnitus severity index (TSI) were measured in all subjects in the beginning and at the end of the 8(th) and 12(th) weeks of the trial. Data was analyzed by repeated measure analysis, paired and independent t-test.Results: Among 51 participants who completed the trial course (28 men, 23 women), carbamazepine, oxcarbazepine and placebo decreased tinnitus severity in 56.6%, 46.2% and 38.5% of patients according to VAS, and in 61.1%, 58.8% and 50% of patients according to TSI, respectively. The effects of carbamazepine and oxcarbazepine were better in the first 8 weeks of treatment. However, their effect on tinnitus did not show any statistical difference in comparison with placebo (P = 0.34, P = 0.28).Conclusion: Carbamazepine and oxcarbazepine are not more effective than placebo in decreasing tinnitus severity.
