1. Environmental risk factors of multiple sclerosis in the Middle East and North Africa region: A systematic review

Hossein Maroufi; Seyyed Hosein Mortazavi; Mohammad Ali Sahraian; Sharareh Eskandarieh

Articles in Press, Accepted Manuscript, Available Online from 21 August 2021

Abstract
  Background: The environmental factors play a role as risk factors of multiple sclerosis (MS). This study aimed at gathering environmental risk factors of MS in the Middle East and North Africa (MENA). Methods: We used MEDLINE and EMBASE databases by a systematic review method. Out of a total of 123 studies, ...  Read More

2. Cost-effectiveness of ocrelizumab for treatment of Iranian patients with relapsing multiple sclerosis

Nayyereh Ayati; Saeed Taheri; Mohammad Ali Sahraian; Shekoufeh Nikfar

Articles in Press, Accepted Manuscript, Available Online from 24 July 2021

Abstract
  Background: The current study desired to conduct an economic analysis on ocrelizumab (OCR), a new relapsing multiple sclerosis (RMS) treatment strategy, in comparison to natalizumab (NTL), as one of the mostly-used disease-modifying therapies (DMTs) in Iran. Methods: A 31-health-state Markov model, based ...  Read More

4. Factors associated with perceived social support of patients with multiple sclerosis

Aikaterin Papa; Ioannis Koutelekos; Spyridoula Stefanidou; Chrysa Chrysovitsanou; Maria Polikandrioti

Volume 20, Issue 2 , Spring 2021, , Pages 64-72

http://dx.doi.org/10.18502/cjn.v20i2.6741

Abstract
  Background: Multiple sclerosis (MS) is an inflammatory chronic disease of the central nervous system (CNS) which is related with unpredictable course and increasing disability. Social support as an available interpersonal resource may help patients with MS. The purposeof the present studywas to evaluate ...  Read More

5. Evaluation of sexual self-efficacy and sexual function in women with multiple sclerosis in Mashhad, Iran, in 2019: A cross-sectional study

Elham Manouchehri; Morteza Saeedi; Khadijeh Mirzaei-Najmabadi

Volume 20, Issue 1 , Winter 2021, , Pages 23-31

http://dx.doi.org/10.18502/cjn.v20i1.6376

Abstract
  Background: In chronic illnesses, sexual dysfunction (SD) is one of the most prevalent complaints. Sexual self-efficacy (SSE) is an individual’s beliefs about his/her ability to perform an effective sexual function and be favorable to their partner. The aim of the present study was to assess SSE ...  Read More

6. Economic sanctions against Iran as an important factor in threatening the health of patients with multiple sclerosis

Mohammad Ali Sahraian; Abdorreza Naser Moghadasi; Sharareh Eskandarieh

Volume 20, Issue 1 , Winter 2021, , Pages 15-22

http://dx.doi.org/10.18502/cjn.v20i1.6375

Abstract
  Background: After intensified economic sanctions against Iran, decreased welfare of patients were more recognizable. The present study was aimed at identifying the challenges and stress level experienced by patients with multiple sclerosis (MS) regarding treatment and health care services in 2018-2019 ...  Read More

7. Clinical outcomes of transverse myelitis with myelin oligodendrocyte glycoprotein antibody versus negative cases among adults in Isfahan, Iran: A comparative study

Masoud Etemadifar; Ahmad Chitsaz; Sahebeh Rajabkhah; Hossein Tavakoli; Arezoo Shafieyoun; Pegah Noorshargh; Mahdieh Afzali

Volume 19, Issue 4 , Autumn 2020, , Pages 173-179

http://dx.doi.org/10.18502/cjn.v19i4.5544

Abstract
  Background: The aim of this study was to evaluate the status of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with transverse myelitis (TM) and compare the clinical and imaging characteristics of MOG immunoglobulin G (IgG)-positive with negative cases. Methods: This cohort study ...  Read More

8. Predictors of suicidal ideation among Iranian patients with multiple sclerosis

Fatemeh Sadat Asgarian; Ali Keyhani; Abdorreza Naser Moghadasi; Moahammad Ali Sahraian; Farnaz Etesam

Volume 19, Issue 4 , Autumn 2020, , Pages 154-161

http://dx.doi.org/10.18502/cjn.v19i4.5541

Abstract
  Background: Considering the high probability of suicidal behaviors in multiple sclerosis (MS) population of other countries and the unlikeliness of its diagnosis in patients with MS by specialists, the current research targets the frequency of suicidal thoughts and mood symptoms in a group of patients ...  Read More

9. Impact of supplementation with "multivitamin-mineral" specially formulated to improve fatigue and inflammatory state in patients with multiple sclerosis: A triple-blind, randomized, placebo-controlled trial

Sama Bitarafan; Elmira Karimi; Abdorreza Naser Moghadasi; Razieh Sadat Kazemi-Mozdabadi; Zinat Mohammadpour; Mohammad Ali Sahraian

Volume 19, Issue 4 , Autumn 2020, , Pages 180-189

http://dx.doi.org/10.18502/cjn.v19i4.5545

Abstract
  Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with the most common complaint of fatigue. A high number of patients with MS are interested in taking dietary supplements as a complementary therapy. We propose a specially formulated supplement for patients ...  Read More

10. Evaluation of safety of rituximab in patients with multiple sclerosis: A retrograde study

Nastaran Majdinasab; Mitra Sadrian; Davood Kashipazha; Maryam Moradi

Volume 19, Issue 3 , Summer 2020, , Pages 103-106

http://dx.doi.org/10.18502/cjn.v19i3.5422

Abstract
  Background: The study aimed to judge the safety and possible side effects of rituximab (RTX) drug in patients with multiple sclerosis (MS). Methods: This retrospective observational study was performed on 91 patients with MS who had been treated with RTX between 2016 and 2019. Each patient was visited ...  Read More

11. The efficacy and safety of oral disease-modifying therapies for relapsing-remitting multiple sclerosis: A systematic review

Rahil Sadat Shahtaheri; Shekoufeh Nikfar; Elahe Khorasani; Mansoureh Sabbagh-Baniazad; Zahra Goudarzi; Maziar Emamikhah

Volume 19, Issue 3 , Summer 2020, , Pages 138-145

http://dx.doi.org/10.18502/cjn.v19i3.5427

Abstract
  Background: Although widely used, first-line injectable medicines for the treatment of multiple sclerosis (MS) remain an issue of efficacy and adherence. Recently, new oral medications for MS have contributed to dramatic improvements in MS treatment. This study aims to evaluate the safety and efficacy ...  Read More

12. A randomized controlled trial investigating the effects of a mediterranean-like diet in patients with multiple sclerosis-associated cognitive impairments and fatigue

Soodeh Razeghi-Jahromi; Rozita Doosti; Zeinab Ghorbani; Roghayyeh Saeedi; Maryam Abolhasani; Naeemeh Akbari; Fatemeh Cheraghi-Serkani; Abdorreza Naser Moghadasi; Amirreza Azimi; Mansoureh Togha; Mohammad Ali Sahraian

Volume 19, Issue 3 , Summer 2020, , Pages 112-121

http://dx.doi.org/10.18502/cjn.v19i3.5424

Abstract
  Background: Among multiple sclerosis (MS) related symptoms and complications, fatigue might impact roughly 90% of patients. Decline in cognitive function is one of the other complications that occur in the first years after disease onset. The Mediterranean diet is one of the well-known anti-inflammatory ...  Read More

13. The prevalence of autoimmune diseases in patients with multiple sclerosis: A cross-sectional study in Qom, Iran, in 2018

Nazanin Ershadinia; Nader Mortazavinia; Sepideh Babaniamansour; Mahdi Najafi-Nesheli; Parto Babaniamansour; Ehsan Aliniagerdroudbari

Volume 19, Issue 3 , Summer 2020, , Pages 98-102

http://dx.doi.org/10.18502/cjn.v19i3.5421

Abstract
  Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases worldwide and various autoimmune comorbidities are reported with MS. The objective of this study is to estimate the prevalence of the autoimmune diseases’ comorbidity in patients with MS. Methods: In this cross-sectional ...  Read More

14. Correlations between developmental test of visual perception-adolescent and adult and visual evoked potential in people with multiple sclerosis

Yasaman Rezaei; Malahat Akbarfahimi; Mojtaba Azimian; Fahimeh Mohaghegh; Mehdi Moghaddasi

Volume 19, Issue 3 , Summer 2020, , Pages 146-149

http://dx.doi.org/10.18502/cjn.v19i3.5428

Abstract
  Background: Optic neuritis (ON) is a common visual sign in multiple sclerosis (MS). Although ON is recovered in most cases, other visual functions such as visual perception are affected and are not fully recovered. The aim of this study is to investigate the relationship between visual evoked potential ...  Read More

15. Association of helicobacter pylori with multiple sclerosis: Protective or risk factor?

Omid Mirmosayyeb; Mahdi Barzegar; Nasim Nehzat; Soroush Najdaghi; Behnaz Ansari; Vahid Shaygannejad

Volume 19, Issue 2 , Spring 2020, , Pages 59-66

http://dx.doi.org/10.18502/cjn.v19i2.4942

Abstract
  Background: Multiple sclerosis (MS) is a common autoimmune inflammatory disease in the central nervous system (CNS) without exact pathology. Environmental factors such as infections have a causal or protective role in MS. Helicobacter pylori (HP) is one of the infections in digestive diseases and previous ...  Read More

16. The relationship between problem-solving ability and fatigue severity in people with multiple sclerosis

Seyed Alireza Derakhshanrad; Emily Piven

Volume 19, Issue 1 , Winter 2020, , Pages 36-39

http://dx.doi.org/10.18502/ijnl.v19i1.3289

Abstract
  Background: The literature speculates that there may be a relationship between cognitive capacities and levels of fatigue in people with multiple sclerosis (MS), which has been under reported. This study has investigated one aspect of cognition by evaluating the association between problem-solving ability ...  Read More

17. Association between single nucleotide polymorphisms rs12722489 and multiple sclerosis in Iranian patients with multiple sclerosis

Habib Ahmadi; Vahid Reza Yassaee; Reza Mirfakhraie; Feyzollah Hashemi-Gorji

Volume 19, Issue 1 , Winter 2020, , Pages 26-31

http://dx.doi.org/10.18502/ijnl.v19i1.3287

Abstract
  Background: Multiple sclerosis (MS) is a complex incurable neurodegenerative disease featuring demyelination of neurons, resulting in impairment of neuron impulses. Recently, an association of two single nucleotide polymorphisms (SNP) (rs2104286 and rs12722489) in interleukin 2 receptor subunit alpha ...  Read More