Special Articles
1. Comparison of serum levels of copper and zinc among multiple sclerosis patients and control group.

Behnaz Sedighi; Hossein Ali Ebrahimi; Ali Akbar Haghdoost; Marzie Abotorabi

Volume 12, Issue 4 , Autumn 2013, Pages 125-128

Abstract
  Background: There have  been  several studies  done  on the role of metals in the occurrence  of multiple sclerosis (MS) disease, but their roles have not been confirmed yet. Because of the lack of information on this issue, this study compared  the  serum  level  of  copper and zinc in MS ...  Read More

Special Articles
2. The effects of trypsin on rat brain astrocyte activation.

Masoud Fereidoni; Farzaneh Sabouni; Ali Moghimi; Shirin Hosseini

Volume 12, Issue 4 , Autumn 2013, Pages 129-135

Abstract
  Background:  Astrocytes are cells within the central nervous system which are activated  in a wide spectrum of infections,  and  autoimmune and  neurodegenerative diseases.In pathologic states, they produce  inflammatory cytokines, chemokines,  and  nitric oxide (NO), and sometimes  they induce ...  Read More

Special Articles
3. Epidemiology of multiple sclerosis in Qom: Demographic study in Iran.

Saeed Rezaali; Ahad Khalilnezhad; Abdorreza Naser Moghadasi; Samira Chaibakhsh; Mohammad Ali Sahraian

Volume 12, Issue 4 , Autumn 2013, Pages 136-143

Abstract
  Background: Recent studies have demonstrated controversial results and somewhat increased frequency of multiple  sclerosis  (MS). We reevaluated  the  files of  MS patients  from Qom Province of Iran in order to investigate the epidemiology of the disease.Methods:  Demographic   and  clinical ...  Read More

Special Articles
4. Psychometric evaluation of the Persian version of the quality of life in epilepsy inventory-31.

Navid Mohammadi; Shiva Kian; Farnoush Davoudi; Seyed Mohammad Ali Akbarian Nia; Marzieh Nojomi

Volume 12, Issue 4 , Autumn 2013, Pages 144-148

Abstract
  Background: Health assessment in patients  with epilepsy (PWE) should  include  both  clinical outcomes and  health related quality of life (HRQOL) measures. The quality of life (QoL) in epilepsy-31 inventory  (QOLIE-31) is widely used for QOL studies  in epilepsy. This study  aims to evaluate ...  Read More

Special Articles
5. The molecular study of IFNβ pleiotropic roles in MS treatment.

Maryam Kay; Zohreh Hojati; Fariba Dehghanian

Volume 12, Issue 4 , Autumn 2013, Pages 149-156

Abstract
  Multiple sclerosis (MS) is one of the most important autoimmune diseases recognized by demyelination and axonal lesion. It is the most common cause of disability in the young population. Various immunomodulatory and immunosuppressive therapies, including different formulations of interferon beta (IFNβ), ...  Read More

Special Articles
6. Pharmacokinetic and pharmacodynamic properties of the new AEDs: A review article.

Majid Ghaffarpour; Hossein Pakdaman; Mohammad Hossein Harirchian; Hossein-Ali Ghelichnia Omrani; Mojdeh Ghabaee; Babak Zamani; Parviz Bahrami; Bahaadin Siroos

Volume 12, Issue 4 , Autumn 2013, Pages 157-165

Abstract
  The new-AEDs, whose developments were motivated following the discovery of the valproate and its marketing in the U.S in 1978, have presented more therapeutic options. There are approximately twenty four FDA-approved antiepileptic drugs for use in patients with epilepsy, five of which were identified ...  Read More

Special Articles
7. Baló's concentric sclerosis in a girl with interesting presentation.

Leila Aghaghazvini; Anahita Sadeghi; Bahman Rasuli; Shirin Aghaghazvini

Volume 12, Issue 4 , Autumn 2013, Pages 166-168

Abstract
  Balo's concentric multiple scleroses (MS) is a rare demyelinating disease and a variant of multiple sclerosis. We report a case with interesting misleading clinical history and typical RI findings of Balo disease. A 19-year-old girl presented with fever and left hemiparesis following dental procedure ...  Read More

Special Articles
8. Sylvian fissure lipoma with angiomatous component and associated brain malformation: A case report.

Shruti Thakur; Ram Gopal Sood; Anupam Jhobta; Sushma Makhaik; Charusmita Thakur

Volume 12, Issue 4 , Autumn 2013, Pages 169-171

Abstract
  Intracranial lipomas are congenital malformations. These uncommon lesions have an incidence of 0.1 to 1.7% of all intracranial tumors. Most cases are located at midline and 5% are along the sylvian fissures. If symptomatic, seizures are the most common symptom. These tumors are slow growing and have ...  Read More

Special Articles
9. Neurological manifestations in patients with antiphospholipid syndrome.

Masoud Etemadifar; Leila Dehghani; Soheil Tahani; Nafiseh Toghianifar; Marzieh Rahaimi; Nahid Eskandari

Volume 12, Issue 4 , Autumn 2013, Pages 172-175

Abstract
  Background: Anti-phospholipids syndrome (APS) is considered a non inflammatory auto-immune disease with a significant thrombophilic risk with varied clinical manifestations. The purpose of the current study was to investigate the frequency of thrombotic and non-thrombotic events in patients with APS.Methods: ...  Read More