Document Type : Short Communication


1 Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran

2 Multiple Sclerosis Clinic, Rofeideh Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

3 Department of Neurology, Iran University of Medical Sciences, Tehran, Iran

4 Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


Background: Optic neuritis (ON) is a common visual sign in multiple sclerosis (MS). Although ON is recovered in most cases, other visual functions such as visual perception are affected and are not fully recovered. The aim of this study is to investigate the relationship between visual evoked potential (VEP) P100 and N70 latencies and visual perception using the Developmental Test of Visual Perception-Adolescent and Adult (DTVP-A) in people with MS.
Methods: In this cross-sectional study, 24 people with ON due to MS, aged 18-50 years old took part. In order to assess the visual perception and optic nerve conductivity, the DTVP-A and the VEP were accomplished, respectively. Pearson’s product-moment correlation coefficient was used to analyze the data.
Results: There was a significant negative correlation between right VEP P100 latency and total score of DTVP-A (r = -0.450, P < 0.05) as well as a significant negative correlation between right VEP P100 latency with visual-motor integration (VMI) subtest of DTVP-A (r = -0.485, P < 0.05).
Conclusion: The visual perception has an important role in safety and independent daily activities. Therefore, determining the related factors is essential. Although the findings of the current study revealed a moderatestatistical correlation between visual perception and right VEP P100 latency, the small sample size might limit the generalization of our findings; therefore, further study is required to confirm our results.


  1. Thompson AJ, Baranzini SE, Geurts J, Hemmer B, Ciccarelli O. Multiple sclerosis. Lancet 2018; 391(10130): 1622-36.
  2. Kale N. Optic neuritis as an early sign of multiple sclerosis. Eye Brain 2016; 8: 195-202.
  3. Barton JL, Garber JY, Klistorner A, Barnett MH. The electrophysiological assessment of visual function in Multiple Sclerosis. Clin Neurophysiol Pract 2019; 4: 90-6.
  4. Vleugels L, Lafosse C, van NA, Charlier M, Ketelaer P, Vandenbussche E. Visuoperceptual impairment in MS patients: Nature and possible neural origins. Mult Scler 2001; 7(6): 389-401.
  5. Reynolds C, Pearson N, Voress J. Developmental Test of Visual Perception-Adolescent and Adult (DTVP-A). Austin, TX:PRO-ED, Inc.; 2002.
  6. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69(2): 292-302.
  7. Seyedian M, Falah M, Nourouzian M, Nejat S, Delavar A, Ghasemzadeh HA. Validity of the Farsi version of Mini-Mental State Examination. J Med Counc I.R. Iran 2008; 25(4): 408-14. [In Persian].
  8. Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Mizota A, et al. ISCEV standard for clinical visual evoked potentials: (2016 update). Doc Ophthalmol 2016; 133(1): 1-9.
  9. Cooray GK, Sundgren M, Brismar T. Mechanism of visual network dysfunction in relapsing-remitting multiple sclerosis and its relation to cognition. Clin Neurophysiol 2020; 131(2): 361-7.