Document Type : Review Article

Authors

1 Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

3 Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

4 Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

5 Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Transient global amnesia (TGA) is a sudden-onset transient memory impairment along with intact neurologic examinations. Even though it is a benign neurologic condition with many differential diagnoses, the incidence rate of TGA is reported to have increased since the onset of the pandemic. Therefore, this systematic scoping review aims to investigate TGA in that context.
Methods: MEDLINE, Scopus, and Google Scholar databases were systematically searched for relevant articles with a string of specified keywords.
Results: The primary search yielded 90 studies. After all the necessary screening rounds were carried out, we were left with six included studies. One study was also identified through a search in other relatively relevant databases. Finally, seven case reports were accepted including three TGA patients with positive and one with negative test for coronavirus disease-2019 (COVID-19), respectively. COVID-19 status was unclear in the others.
Conclusion: The reported COVID-19 positive cases had presentations similar to those with TGA before the pandemic. Therefore, we think that TGA might occur concomitantly with the COVID-19 infection or due to the psychological impact of the pandemic. In the confirmed cases of TGA and COVID-19, the abnormal findings may be due to COVID-19 infection. However, the reports were not as complete as desired. Therefore, providing the readers with more detailed reports in future cases is recommended.

Keywords

  1. Pandamooz S, Jurek B, Meinung CP, Baharvand Z, Sahebi Shahem-Abadi A, Haerteis S, et al. Experimental models of SARS-CoV-2 infection: Possible platforms to study COVID-19 pathogenesis and potential treatments. Annu Rev Pharmacol Toxicol 2022; 62: 25-53.
  2. Hooshmandi E, Borhani-Haghighi A. The case is much more baffling than we think. Eur Neurol 2020; 83(2): 216-7.
  3. Asadi-Pooya AA, Simani L. Central nervous system manifestations of COVID-19: A systematic review. J Neurol Sci 2020; 413: 116832.
  4. Asadi-Pooya AA, Akbari A, Emami A, Lotfi M, Rostamihosseinkhani M, Nemati H, et al. Long COVID syndrome-associated brain fog. J Med Virol 2022; 94(3): 979-84.
  5. Shahjouei S, Tsivgoulis G, Farahmand G, Koza E, Mowla A, Vafaei SA, et al. SARS-CoV-2 and stroke characteristics: A report from the Multinational COVID-19 Stroke Study Group. Stroke 2021; 52(5): e117-e130.
  6. Sabayan B, Moghadami M, Assarzadegan F, Komachali SH, Poorsaadat L, Babaeepour Z, et al. COVID-19 respiratory illness and subsequent cerebrovascular events, the initial iranian experience. J Stroke Cerebrovasc Dis 2021; 30(1): 105454.
  7. Ostovan VR, Foroughi R, Rostami M, Almasi-Dooghaee M, Esmaili M, Bidaki AA, et al. Cerebral venous sinus thrombosis associated with COVID-19: A case series and literature review. J Neurol 2021; 268(10): 3549-60.
  8. Mowla A, Shakibajahromi B, Shahjouei S, Borhani-Haghighi A, Rahimian N, Baharvahdat H, et al. Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series. J Neurol Sci 2020; 419: 117183.
  9. Fadakar N, Ghaemmaghami S, Masoompour SM, Shirazi YB, Akbari A, Hooshmandi S, et al. A First case of acute cerebellitis associated with coronavirus disease (COVID-19): a case report and literature review. Cerebellum 2020; 19(6): 911-4.
  10. Khodamoradi Z, Hosseini SA, Gholampoor Saadi MH, Mehrabi Z, Sasani MR, Yaghoubi S. COVID-19 meningitis without pulmonary involvement with positive cerebrospinal fluid PCR. Eur J Neurol 2020; 27(12): 2668-9.
  11. Sharifian-Dorche M, Huot P, Osherov M, Wen D, Saveriano A, Giacomini PS, et al. Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic. J Neurol Sci 2020; 417: 117085.
  12. Asadi-Pooya AA, Kouhanjani MF, Nemati H, Emami A, Javanmardi F. A follow-up study of patients with COVID-19 presenting with seizures. Epilepsy Behav 2021; 122: 108207.
  13. Arena JE, Rabinstein AA. Transient global amnesia. Mayo Clin Proc 2015; 90(2): 264-72.
  14. Quinette P, Guillery-Girard B, Dayan J, de lS, V, Marquis S, Viader F, et al. What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases. Brain 2006; 129(Pt 7): 1640-58.
  15. Thakur V, Ratho RK, Kumar P, Bhatia SK, Bora I, Mohi GK, et al. Multi-Organ involvement in COVID-19: Beyond pulmonary manifestations. J Clin Med 2021; 10(3): 446.
  16. Gass A, Gaa J, Hirsch J, Schwartz A, Hennerici MG. Lack of evidence of acute ischemic tissue change in transient global amnesia on single-shot echo-planar diffusion-weighted MRI. Stroke 1999; 30(10): 2070-2.
  17. Huber R, Aschoff AJ, Ludolph AC, Riepe MW. Transient Global Amnesia. Evidence against vascular ischemic etiology from diffusion weighted imaging. J Neurol 2002; 249(11): 1520-4.
  18. Werner R, Keller M, Woehrle JC. Increased incidence of transient global amnesia during the Covid-19 crisis? Neurol Res Pract 2020; 2(1): 26.
  19. Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med 2018; 169(7): 467-73.
  20. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions. 2nd Chichester, UK: John Wiley & Sons, 2019.
  21. Ramanathan RS, Wachsman A. Coronavirus disease-19 (COVID-19) related acute stroke causing transient global amnesia. J Stroke Cerebrovasc Dis 2021; 30(5): 105738.
  22. Hussein HM. Transient global amnesia as a possible first manifestation of COVID-19. Neurohospitalist 2021; 11(1): 84-6.
  23. Nishizawa T, Kawakami A, Taguchi T, Osugi Y. Transient global amnesia with bilateral hippocampal lesions during the COVID-19 global outbreak. J Gen Fam Med 2021; 22(3): 154-5.
  24. Yang C, Zhang J, Gaonkar S. Transient global amnesia associated with migraine triggered by anxiety under the effects of the coronavirus disease 2019 (COVID-19) panndemic: A case report. MOJ Clin Med Case Rep 2020; 10(3): 74-76.
  25. Ravaglia S, Zito A, Ahmad L, Canavero I. How to forget a "traumatic" experience: A case report of transient global amnesia after nasopharyngeal swab for Coronavirus disease 19. BMC Neurol 2021; 21(1): 266.
  26. Gentile E, Delussi M, Abagnale C, Caponnetto V, De CF, Frattale I, et al. Migraine during COVID-19: Data from second wave pandemic in an Italian cohort. Brain Sci 2021; 11(4): 482.
  27. Chowdhury D, Datta D. Managing migraine in the times of COVID-19 pandemic. Ann Indian Acad Neurol 2020; 23(Suppl 1): S33-S39.
  28. Dhamoon MS, Thaler A, Gururangan K, Kohli A, Sisniega D, Wheelwright D, et al. Acute cerebrovascular events with COVID-19 infection. Stroke 2021; 52(1): 48-56.
  29. Jain TP, Patel R, Gawarikar Y. Transient global amnesia: Diffusion MRI findings. Indian J Radiol Imaging 2018; 28(1): 6-9.
  30. Sander K, Sander D. New insights into transient global amnesia: Recent imaging and clinical findings. Lancet Neurol 2005; 4(7): 437-44.
  31. Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, et al. Impact of COVID-19 pandemic on mental health in the general population: A systematic review. J Affect Disord 2020; 277: 55-64.
  32. Werner R, Woehrle JC. Transient global amnesia and Covid-19. J Neurol Sci 2021; 428: 117562.
  33. Spiegel DR, Smith J, Wade RR, Cherukuru N, Ursani A, Dobruskina Y, et al. Transient global amnesia: Current perspectives. Neuropsychiatr Dis Treat 2017; 13: 2691-703.