Document Type : Short Communication
Authors
Department of Neurology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
Abstract
Background: Migraine is a common neurological disorder that affects 12-15 percent of the general population. There are few studies in the literature comparing various characteristics of patients with migraine with and without metabolic syndrome with variable results. This study identifies distinct patterns in migraine frequency, severity, or triggers associated with patients with migraine with and without metabolic syndrome.
Methods: This was a cross-sectional study and patients fulfilling the International Classification of Headache Disorders-3rd edition (ICHD-3) for defining migraine were included in the study. National Cholesterol Education Program (NCEP)-Third Report was used to define metabolic syndrome. Headache severity [visual analog scale (VAS) scoring] and disability grading [Migraine Disability Assessment (MIDAS) scoring] were noted. We compared various clinical parameters in patients with migraine with and without metabolic syndrome.
Results: A total of 204 patients with migraine were recruited. We found that the majority of migraineurs were women (female to male ratio = 4.2:1), with a mean age of 28 years (12-58). A total of 25 patients with migraine (12.25%) had metabolic syndrome. In migraineurs with metabolic syndrome, the mean age at onset, female preponderance, and mean duration of illness were significantly higher than migraineurs without metabolic syndrome. Those with and without metabolic syndrome did not significantly differ from one another in terms of migraine triggers, frequency, severity of headache, or disability severity.
Conclusion: This study showed that metabolic syndrome was present in about 12% of patients with migraine. Individuals with metabolic syndrome had longer mean durations of illness and female preponderance and were older at initial presentation compared to migraineurs without metabolic syndrome.
Keywords
Main Subjects
- Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001; 41(7): 646-57.
- Ashina M, Katsarava Z, Do TP, Buse DC, Pozo-Rosich P, Özge A, et al. Migraine: epidemiology and systems of care. Lancet 2021; 397(10283): 1485-95.
- Correction to Lancet Neurol 2018; 17(11): 954-76. Lancet Neurol 2021; 20(12).
- Aurora S, Kori S, Barrodale P, Nelsen A, McDonald S. Gastric stasis occurs in spontaneous, visually induced, and interictal migraine. Headache 2007; 47(10): 1443-6.
- Blau JN. Migraine: theories of pathogenesis. Lancet 1992; 339(8803): 1202-7.
- Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23(5): 469-80.
- Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech 2009; 2(5-6): 231-7.
- Marmura MJ. Systemic abnormalities in migraine: what comes first? Neurologist 2009; 15(2): 53-4.
- Del Moro L, Rota E, Pirovano E, Rainero I. Migraine, Brain Glucose Metabolism and the "Neuroenergetic" Hypothesis: A Scoping Review. J Pain 2022; 23(8): 1294-317.
- Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, et al. Migraine and cardiovascular disease: a population-based study. Neurology 2010; 74(8): 628-35.
- Bhoi SK, Kalita J, Misra UK. Metabolic syndrome and insulin resistance in migraine. J Headache Pain 2012; 13(4): 321-6.
- Salmasi M, Amini L, Javanmard SH, Saadatnia M. Metabolic syndrome in migraine headache: A case-control study. J Res Med Sci 2014; 19(1): 13-7.
- López-de-Andrés A, Luis Del Barrio J, Hernández-Barrera V, de Miguel-Díez J, Jimenez-Trujillo I, Martinez-Huedo MA, et al. Migraine in adults with diabetes; is there an association? Results of a population-based study. Diabetes Metab Syndr Obes 2018; 11: 367-74.
- Zelissen PM, Koppeschaar HP, Lips CJ, Hackeng WH. Calcitonin gene-related peptide in human obesity. Peptides 1991; 12(4): 861-3.
- Gallai V, Sarchielli P, Trequattrini A, Paciaroni M, Usai F, Palumbo R. Neuropeptide Y in juvenile migraine and tension-type headache. Headache 1994; 34(1): 35-40.
- Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 2005; 69(1): 29-35.
- Lippi G, Mattiuzzi C, Cervellin G. C-reactive protein and migraine. Facts or speculations? Clin Chem Lab Med 2014; 52(9): 1265-72.
- Facey A, Dilworth L, Irving R. A review of the leptin hormone and the association with obesity and diabetes mellitus. J Diabetes Metab 2017; 8(3).
- Pisanu C, Preisig M, Castelao E, Glaus J, Cunningham JL, Del Zompo M, et al. High leptin levels are associated with migraine with aura. Cephalalgia 2017; 37(5): 435-41.
- Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia: an international journal of headache 2018; 38(1): 1-211.
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285(19): 2486-97.
- Guldiken B, Guldiken S, Taskiran B, Koc G, Turgut N, Kabayel L, et al. Migraine in metabolic syndrome. Neurologist 2009; 15(2): 55-8.
- Winsvold BS, Sandven I, Hagen K, Linde M, Midthjell K, Zwart JA. Migraine, headache and development of metabolic syndrome: an 11-year follow-up in the Nord-Trøndelag Health Study (HUNT). Pain 2013; 154(8): 1305-11.
- Celikbilek A, Borekci E, Kozan M, Celikbilek M. Assessment of metabolic syndrome in patients with migraine in central Anatolia. Eur J Gen Med 2015; 12(2): 152-6.
- Maghbooli M, Jameshorani M, Afshar S, Kamali K. The prevalence of metabolic syndrome parameters and their association with headache characteristics among migraineurs. Curr J Neurol 2021; 20(4): 190-201.
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