Original Article
Payam Sarraf; Mahan Shafie; Ghasem Farahmand; Mahsa Mayeli; Mojtaba Shahbazi; Hana Magrouni; Melika Jameie; Babak Ghelichnia Emrani; Maryam Rashidi-Jazani
Abstract
Background: Isaacs’ syndrome is a form of generalized peripheral nerve hyperexcitability (PNH) causing increased and continuous muscle activity characterized by muscle twitching, stiffness, cramps, myokymia, and pseudomyotonia. Herein, we aimed to review the clinical and paraclinical aspects of Isaacs’ ...
Read More
Background: Isaacs’ syndrome is a form of generalized peripheral nerve hyperexcitability (PNH) causing increased and continuous muscle activity characterized by muscle twitching, stiffness, cramps, myokymia, and pseudomyotonia. Herein, we aimed to review the clinical and paraclinical aspects of Isaacs’ syndrome in a number of cases.Methods: We reported a series of 12 patients with Isaacs’ syndrome, including their clinical features, electrophysiological findings, laboratory parameters, malignancy work-up, and therapeutic management.Results: In all cases, clinical and electrodiagnostic assessment was suggestive of Isaacs’ syndrome. Of the 12 studied cases, 5 patients were positive for both leucine-rich glioma inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies, 5 patients were CASPR2 positive and LGI1 negative, and 1 had borderline positive titers for CASPR2 with negative LGI1 antibody. The search for underlying malignancies was inconclusive in all subjects. After symptomatic treatment, mostly with carbamazepine or gabapentin, immunotherapies with double filtration plasmapheresis or Intravenous immunoglobulin (IVIG) provided favorable outcomes. Ultimately, all subjects fully recovered after 3-6 months of follow-up and all signs and symptoms resolved.Conclusion: Despite the rarity of the disease, our results provide valuable information for understanding the epidemiological, clinical, and paraclinical features of Isaacs’ syndrome.
Original Article
Seyed Mohammad Sadegh Hosseini; Mohsen Sarhady; Sahar Nurani-Gharaborghe
Abstract
Background: An effective and reliable assessment tool is essential for evaluating the leisure activities of patients. The purpose of this study is to assess the validity and reliability of the Iranian-developed version of leisure questionnaire for people with multiple sclerosis (MS).Methods: Psychometric ...
Read More
Background: An effective and reliable assessment tool is essential for evaluating the leisure activities of patients. The purpose of this study is to assess the validity and reliability of the Iranian-developed version of leisure questionnaire for people with multiple sclerosis (MS).Methods: Psychometric methods were used to assess face, content, differential, and convergent validity, as well as test-retest reliability. The study used SPSS software to enter data and assessed content validity using descriptive characteristics and the intraclass correlation coefficient (ICC) based on ratings by experts. Independent t-tests and analysis of variance (ANOVA) were used to analyse the differential validity, while the Pearson test was used to analyse the convergent validity by comparing it with the Nottingham Leisure Questionnaire (NLQ). The study calculated the reliability of the questionnaire using the paired t-test and ICC.Results: The subjects were 60 patients with MS. The content validity analysis showed a single measure validity coefficient of 0.158 and an average measure coefficient of 0.751, both of which were statistically significant. The results of the differential validity analysis for the entire questionnaire were also significant (t = -3.058, P = 0.003). Additionally, the convergent validity and reliability of the questionnaire were 0.92 and 0.82, respectively.Conclusion: The 50-item leisure questionnaire designed for patients with MS demonstrated good validity and reliability. Therefore, it can be used as an effective research tool for exploring the leisure activities of individuals with MS.
Original Article
Sepideh Paybast; Melika Jameie; Mojtaba Shahbazi; Mohammad Amin Habibi; Seyed Ehsan Mohammadianinejad; Mohammad Hossein Harirchian
Abstract
Background: Multiple sclerosis (MS) is the most common cause of non-traumatic disability in young individuals. There are limited reports of developing demyelinating events following the coronavirus disease 2019 (COVID-19) vaccination.Methods: We reported all individuals (n = 8) with new MS diagnoses ...
Read More
Background: Multiple sclerosis (MS) is the most common cause of non-traumatic disability in young individuals. There are limited reports of developing demyelinating events following the coronavirus disease 2019 (COVID-19) vaccination.Methods: We reported all individuals (n = 8) with new MS diagnoses with recent exposure (≤ 6 weeks) to the Sinopharm (BBIBP-CorV) vaccine between September 2021 and June 2022. We also reviewed the related literature published as of September 2023.Results: Of 338 newly diagnosed patients with MS who attended our tertiary referral MS center during the study period, 8 (2.36%) had their first demyelinating attack with a median interval of 2 [2.0, 4.0] weeks following the Sinopharm vaccine (sex ratio 1:1, median age: 20.5 [18.0, 27.0] years). No personal or family history of autoimmune/neurological disorders was documented, except for one patient's history of a previous potential demyelinating event and another's family history of immune thrombocytopenic purpura (ITP). All patients had demyelinating brain MRI lesions, and 4 had cervical spinal cord involvement. The brain areas most commonly affected were the periventricular and subcortical regions. Positive oligoclonal bands (OCBs) in all patients supported the MS diagnosis. All patients were diagnosed with relapsing-remitting MS and received intravenous methylprednisolone (IVMP) alone or in combination with plasma exchange (3/8). Rituximab was the most frequently used disease-modifying treatment (3/8).Conclusion: This study provides preliminary evidence of a potential association between the Sinopharm vaccine and the initial manifestations of MS. However, further larger-scale studies with control groups and long-term follow-ups are needed to confirm this association and determine the underlying mechanisms.
Original Article
Ahmad Chitsaz; Mohammad Reza Najafi; Farzaneh Habibi; Sajad Amirhajloo
Abstract
Background: A large percentage of patients with Parkinson's disease (PD) suffer from excessive daytime sleepiness (EDS). This study aims to compare the effectiveness of modafinil and methylphenidate on EDS and side effects.Methods: Fifty nine patients with PD and EDS [Epworth Sleepiness Scale (ESS) more ...
Read More
Background: A large percentage of patients with Parkinson's disease (PD) suffer from excessive daytime sleepiness (EDS). This study aims to compare the effectiveness of modafinil and methylphenidate on EDS and side effects.Methods: Fifty nine patients with PD and EDS [Epworth Sleepiness Scale (ESS) more than 9] were recruited in a double-blind placebo controlled trial. Twenty-two patients received modafinil 200 mg daily, twenty-six patients received methylphenidate 10 mg daily, and 11 patients received placebo for 6 weeks. Pittsburgh Sleep Quality Index (PSQI) and ESS were filled out at baseline and 6 weeks later.Results: There was no significant difference in demographics, PSQI, and ESS variables at baseline. The mean of ESS scores decreased significantly in modafinil (17.36 ± 5.05 vs. 10.55 ± 4.62, P < 0.001) and methylphenidate (16.27 ± 5.40 vs. 12.23 ± 6.28, P < 0.001) groups after 6-week trial, compared with control group (14.27 ± 4.49 vs. 14.09 ± 4.46, P = 0.710). The effectiveness of modafinil and methylphenidate on improving daytime sleepiness and night sleep of patients was not significantly different.Conclusion: Both modafinil and methylphenidate were effective drugs in improving EDS and quality of sleep without significant difference in efficiency and side effects.
Original Article
Kiana Amani; Mojtaba Shahbazi; Atefeh Behkar; Ghasem Farahmand; Shima Ghafouri; Sanaz Heydari; Maryam Kaeedi; Hana Magrouni; Fatemeh Alizadeh; Mojdeh Ghabaee; Payam Sarraf; Abbas Tafakhori; Hamed Amirifard; Sakineh Ranji-Burachaloo; Seyed Ehsan Mohammadianinejad; Melika Jameie; Mohammad Hossein Harirchian
Abstract
Background: COVID-19 was associated with an increased number of patients with mucormycosis (MCR), followed by septic cavernous sinus thrombosis (SCST). We evaluated the association between anticoagulation (AC) and mortality/morbidity of COVID-19-associated MCR (CAM)-induced SCST.Methods: In this retrospective ...
Read More
Background: COVID-19 was associated with an increased number of patients with mucormycosis (MCR), followed by septic cavernous sinus thrombosis (SCST). We evaluated the association between anticoagulation (AC) and mortality/morbidity of COVID-19-associated MCR (CAM)-induced SCST.Methods: In this retrospective study, neurological sequelae, functional outcomes, and in-hospital mortality were compared between AC receivers and non-receivers. In addition, the association between AC and survivability was examined.Results: Twenty-nine patients (17 male; mean age: 51.27 years) with CAM-induced SCST were included in the study. The median intervals between COVID-19 and MCR, and COVID-19 and SCST were 19 and 27 days, respectively. Among AC recipients, the interval between SCST and AC initiation was 18 days, with an AC duration of 37 days. Baseline and management-related characteristics were comparable between AC recipients and non-recipients (P > 0.050). AC receivers (n = 15) and non-receivers (n = 14) did not significantly differ in terms of the proportion of sequelae (6/15 vs. 5/14; P = 1.000), complete recovery (2/15 vs. 4/14; P = 0.687), and in-hospital mortality (3/15 vs. 3/14; P > 0.999). Nevertheless, AC recipients had a longer hospital stay (72.0 vs. 35.5; P = 0.016). AC-related characteristics (AC receiving, type, early initiation, and duration) were not significantly different between survivors and non-survivors, or between recovered and disabled patients.Conclusion: In our study, CAM-induced SCST in-hospital mortality/morbidity did not differ between AC receivers and non-receivers. AC characteristics were not different between survivors and non-survivors, or recovered and disabled patients. However, the small sample size may have limited the ability to detect significant differences, leading to inconclusive results.
Original Article
Hoda Faraji; Isa Akbarzadeh; Mehdi Yaseri; Mohammad Ali Sahraian; Shekoufeh Nikfar
Abstract
Background: Providing informal care can deeply influence, both physically and emotionally, the quality of life (QoL) of caregivers, especially when the disease becomes chronic. CarerQol-7D is one of the most common instruments for measuring informal care. We aimed to develop a Persian version of the ...
Read More
Background: Providing informal care can deeply influence, both physically and emotionally, the quality of life (QoL) of caregivers, especially when the disease becomes chronic. CarerQol-7D is one of the most common instruments for measuring informal care. We aimed to develop a Persian version of the CarerQol-7D in the context of Iranian caregivers of patients with multiple sclerosis (MS). To this end, we investigated the validity and reliability of the mentioned instrument.Methods: In this cross-sectional study using consecutive sampling method, the backward-forward translation method was used to achieve the Persian version of CarerQol-7D. Structural equation modeling (SEM) was used to perform confirmatory factor analysis (CFA). Cronbach’s alpha was also reported for this instrument for the evaluation of internal consistency.Results: This tool was evaluated based on a sample of 452 caregivers of patients with MS from Sina Hospital, Tehran, Iran. Most of the participants were men (62.6%) and spouses of patients (56.6%). Based on the correlation of caregivers’ characteristics, the clinical validity of this tool was observed to be relatively moderate. The Cronbach’s alpha for this tool was estimated to be 65%. The normed fit index (NFI) (0.906), relative fit index (RFI) (0.812), incremental fit index (IFI) (0.948), Tucker-Lewis index (TLI) (0.892), comparative fit index (CFI) (0.946), and root mean square error of approximation (RMSEA) (0.049) were the model fit indices for the CarerQol-7D instrument.Conclusion: The findings showed good internal consistency and strong validity of the CarerQol-7D. Thus, we suggest researchers use this instrument to measure the QoL of caregivers for use in economic evaluations.
Original Article
Ancil George Thomas; Madhusudanan Mohan; Reji Thomas
Abstract
Background: The etiological factors leading to progressive supranuclear palsy (PSP) are poorly understood. This study aims to evaluate the role of various risk factors in patients with PSP.Methods: A case-control study was conducted over a period of two years from March 2016 to March 2018. The cases ...
Read More
Background: The etiological factors leading to progressive supranuclear palsy (PSP) are poorly understood. This study aims to evaluate the role of various risk factors in patients with PSP.Methods: A case-control study was conducted over a period of two years from March 2016 to March 2018. The cases were recruited independently by two senior neurologists and a consensus was then reached after discussion for their inclusion. The controls were free of parkinsonian features or dementia and matched by age (± 3 years), sex, and race with the cases. The study population was then interviewed using a standard questionnaire for various possible risk factors. Variables with a significance (P ≤ 0.05) in univariate analysis were considered for bivariate analysis, multivariate analysis, and logistic-regression analysis.Results: A total of 51 cases with an equal number of controls were included in this study. Ten separate variables that included poor educational status, well water, smoking, tapioca, bakery/fast food, tea ≥ 5 cups/day, personality, exposure to pets, exposure to cattle, and family history of stroke were found to show statistical significance after univariate analysis. Among these, tapioca consumption, fast food and bakery items consumption, type A personality, and family history of stroke were found significant after adjusting for the confounding factors.Conclusion: The possible etiological factors that have a relevance in the causation of PSP as borne out in our study include dietary habits such as tapioca, fast food, and bakery items consumption, family history of stroke, and type A personality trait.
Original Article
Mahnaz Bayat; Etrat Hooshmandi; Najmeh Karimi; Moosa Rahimi; Reza Tabrizi; Tahereh Asadabadi; Mohammad Saied Salehi; Seyedeh Shaghayegh Zafarmand; Maryam Owjfard; Carlos Garcia Esperon; Neil Spratt; Christopher Levi; Afshin Borhani-Haghighi
Abstract
Background: Inflammation is the major contributor to the pathophysiology of ischemic stroke (IS). Long non-coding ribonucleic acids (lncRNAs) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and tumor necrosis factor and heterogeneous nuclear ribonucleoprotein L-related immunoregulatory ...
Read More
Background: Inflammation is the major contributor to the pathophysiology of ischemic stroke (IS). Long non-coding ribonucleic acids (lncRNAs) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and tumor necrosis factor and heterogeneous nuclear ribonucleoprotein L-related immunoregulatory (THRIL) have been demonstrated to be up-regulated in inflammation and atherosclerosis. Therefore, we aimed to study the expression profile of these lncRNAs after IS.Methods: This observational case-control study was conducted in Namazi Hospital, Shiraz, Iran. The real-time polymerase chain reaction (RT-PCR) measured the sequential changes in circulating levels of MALAT1 and THRIL on days 1, 3, and 5 after IS. The receiver operating characteristic (ROC) curve analysis was used to estimate the diagnostic and prognostic potential of lncRNAs with the area under the curve (AUC).Results: In patients with IS, the relative MALAT1 and THRIL expressions were significantly higher than the controls (P < 0.001 and P < 0.01, respectively), on days 1, 3, and 5 after stroke. We showed a significantly increase in lncRNAs expression on day five compared to days 1 and 3 after stroke. Moreover, a positive correlation was detected between MALAT1 expression and time within the first 24 hours after stroke (r = 0.27, P = 0.03). Logistic regression analysis showed a significant positive association between MALAT1 and THRIL and the risk of stroke evolution. We found a potential diagnostic marker for MALAT1 with an AUC of 0.78.Conclusion: We demonstrated the significant sequential upregulation in MALAT1 and THRIL expression on days 1, 3, and 5 after IS with a significant positive association with the risk of stroke. MALAT1 also significantly correlated with time within the first 24 hours after stroke.
Letter to the Editor
Nazila Malekian; Asker Ghorbani
Letter to the Editor
Seyed Jalaleddin Hadei; Bardiya Ghaderi-Yazdi; Shahriar Nafissi
Original Article
Ghasem Farahmand; Atefeh Behkar; Hassan Hashemi; Mahsa Ghajarzadeh; Samira Raminfard; Mojtaba Shahbazi; Payam Sarraf
Articles in Press, Accepted Manuscript, Available Online from 10 June 2024
Abstract
Background: Carpal tunnel syndrome (CTS) is a common peripheral nerve entrapment disorder that is diagnosed using clinical signs and symptoms and confirmed via nerve conduction studies (NCSs). While NCS is a semi-invasive procedure, magnetic resonance imaging (MRI) is a non-invasive diagnostic tool that ...
Read More
Background: Carpal tunnel syndrome (CTS) is a common peripheral nerve entrapment disorder that is diagnosed using clinical signs and symptoms and confirmed via nerve conduction studies (NCSs). While NCS is a semi-invasive procedure, magnetic resonance imaging (MRI) is a non-invasive diagnostic tool that detects macroscopic nerve abnormalities and evaluates a patient's surgical or medication treatment options. This study assessed magnetic resonance neurography (MRN)’s diagnostic and grading value by comparing it to electrodiagnostic studies in patients with CTS and healthy individuals.Methods: This was a cross-sectional study on 27 wrists with CTS and 27 healthy wrists. After history taking and physical examination, we employed an NCS to confirm and determine the severity of CTS, then MRN and diffusion tensor imaging (DTI) were used to calculate apparent diffusion coefficient (ADC), fractional anisotropy (FA), and cross-sectional area (CSA).Results: 18 patients with CTS (27 median nerves) and 15 healthy controls (27 median nerves) were evaluated. The mean FA in the CTS group was significantly lower (0.38 ± 0.05 vs. 0.45 ± 0.06, P < 0.001). The mean CSA and ADC were higher in patients with CTS but not statistically significant. FA’s diagnostic cut-off was 0.42, with a sensitivity of 70.4% and a specificity of 63%.Conclusion: MRN with DTI can be an effective and non-invasive diagnostic technique for the detection of CTS. The FA measure demonstrated adequate sensitivity and specificity for differentiating patients with CTS from healthy individuals.
Original Article
Mohammad Javad Gholamzadeh; Etrat Hooshmandi; Zahra Ghahramani; Reza Fereidooni; Alireza Rezvani; Maryam Vasaghi-Gharamaleki; Hossein Molavi-Vardanjani; Sadegh Shirian; Nima Fadakar; Vahid Reza Ostovan; Maryam Poursadeghfard; Nahid Ashjazadeh; Afshin Borhani-Haghighi
Articles in Press, Accepted Manuscript, Available Online from 08 June 2024
Abstract
AbstractBackground: Several laboratory markers derived from a complete blood count (CBC) have been proposed as potential indicators for assessing the risk of cerebral venous thrombosis (CVT). However, limited and conflicting evidence exists regarding this association. This study aimed to evaluate the ...
Read More
AbstractBackground: Several laboratory markers derived from a complete blood count (CBC) have been proposed as potential indicators for assessing the risk of cerebral venous thrombosis (CVT). However, limited and conflicting evidence exists regarding this association. This study aimed to evaluate the role of CBC parameters in CVT development and their link to disease characteristics.Methods: This case-control study included patients diagnosed with CVT between March 2018 and March 2021. All participants with CVT were registered in the organized registry system at the Neurology Research Center of Shiraz University of Medical Sciences, Shiraz, Iran (CVT registry code: 9001013381). The control group consisted of age- and sex-matched individuals without systemic diseases. CBC results from the control group and the first recorded hospital CBC of the patient group were collected.Results: The study included 295 patients with CVT [49 with idiopathic CVT (iCVT) and 246 with secondary CVT (sCVT)] and 341 healthy individuals. Among the CVT group, 72.54% were women. Patients with CVT had higher red cell distribution width (RDW) and lower red blood cell (RBC) count, hemoglobin (Hb) levels, and hematocrit compared to the non-CVT group. In iCVT cases, male gender, RBC count, Hb levels, and hematocrit were notably higher compared to sCVT cases. Logistic regression analysis showed that female gender, smoking, and higher hematocrit values were associated with increased probability of iCVT.Conclusion: The study suggests that certain CBC parameters may serve as potential markers for assessing CVT risk and differentiating between iCVT and sCVT cases. Validation and further research are needed to explore the underlying mechanisms.
Original Article
Sajjad Ghane Ezabadi; Fereshteh Ashtari; Seyed Mohammad Baghbanian; Nastaran Majdi-Nasab; Elham Madreseh; Hamidreza Hatamian; Fardin Faraji; Asghar Bayati; Hoda Kamali; Ehsan Sharifipour; Hossein Mozhdehipanah; Mohammad Amin Shahrbaf; Saeideh Ayoubi; Mohammad Ali Sahraian; Sharareh Eskandarieh
Articles in Press, Accepted Manuscript, Available Online from 18 June 2024
Abstract
Background: Multiple sclerosis (MS) predominantly affects women of childbearing age, significantly impacting their quality of life (QOL). The diagnosis of MS can influence pregnancy intention, and the level of disability associated with MS may change before and after pregnancy. This study aims to ...
Read More
Background: Multiple sclerosis (MS) predominantly affects women of childbearing age, significantly impacting their quality of life (QOL). The diagnosis of MS can influence pregnancy intention, and the level of disability associated with MS may change before and after pregnancy. This study aims to analyze the reproductive characteristics of Iranian female patients with MS (PwMS) and their association with the Expanded Disability Status Scale (EDSS) and pregnancy tendency, providing valuable insights into disease progression and the development of tailored treatments.Methods: A cross-sectional study was conducted using data from the nationwide MS registry of Iran (NMSRI) from 2018 to 2021. Patients without a documented history of pregnancy, MS type, or EDSS score were excluded from the study. Various statistical methods, including nonparametric tests, the generalized estimating equation (GEE) model, and multiple logistic regression, were employed to analyze the data.Results: The study included 1120 PwMS with a median diagnostic age of 31 and a disease duration of 6 years. The majority had relapsing-remitting MS (RRMS) and the mean EDSS score at bassline was 1.5 ± 1.4. A history of pregnancy or abortion was associated with higher EDSS scores. Multiparity before MS diagnosis was linked to EDSS score ≥ 5, while this EDSS range was associated with decreased parity after MS diagnosis (all P-values < 0.05).Conclusion: Pregnancy and parity can affect the disability in female PwMS irrespective of clinical symptoms, diagnosis age, and MS type. Moreover, the chance of parity may be affected by a higher disability score, which should be considered in the clinical setting.
Original Article
Zoofa Zayani; Etrat Hooshmandi; Afshin Borhani-Haghighi; Mousa Rahimi; Vahid Reza Ostovan; Nima Fadakar; Reza Tabrizi; Mahnaz Bayat; Seyedeh Shamim Hojati; Negin Gharbi; Hamideh Mahmoudinasab
Articles in Press, Accepted Manuscript, Available Online from 06 July 2024
Abstract
Background: Long non-coding ribonucleic acids (lncRNAs) have been implicated as possible circulating stroke indicators. This study focused on the expression status of antisense non-coding ribonucleic acid in the INK4 locus (ANRIL) and myocardial infarction associated transcript (MIAT) in patients with ...
Read More
Background: Long non-coding ribonucleic acids (lncRNAs) have been implicated as possible circulating stroke indicators. This study focused on the expression status of antisense non-coding ribonucleic acid in the INK4 locus (ANRIL) and myocardial infarction associated transcript (MIAT) in patients with cerebral venous thrombosis (CVT).Methods: In this study, fifty patients with CVT and one hundred age/gender-matched individuals as controls were included. The circulating levels of ANRIL and MIAT in the first 24 hours after admission were evaluated using the quantitative real-time polymerase chain reaction (RT-PCR) method. We compared the expression levels of ANRIL and MIAT between patients and controls using the independent two-sample t-test. Subgroup analysis was used to investigate the association of lncRNAs with clinical characteristics in patients with CVT. Receiver operating characteristic (ROC) curve analyses were conducted to evaluate the diagnostic value of two lncRNAs in patient assessment.Results: The relative expression of lncRNAs ANRIL and MIAT significantly decreased in patients compared to the control. ANRIL and MIAT were shown as potential markers for discriminating patients with CVT from the healthy controls with an area under the curve (AUC) of 0.98 and 0.99, respectively.Conclusion: For the first time, we found down-regulation and diagnostic potential of lncRNAs-ANRIL and MIAT in the blood of patients with CVT.
Original Article
Hossein Pourshahriar; Banafsheh Khalili; Omid Shokri; Farzad Fatehi
Articles in Press, Accepted Manuscript, Available Online from 17 July 2024
Abstract
Background: Stress has been known as a risk factor for the onset and modification of autoimmune disorders such as myasthenia gravis (MG). However, the patients can control their stress and improve their quality of life (QOL) using some factors such as psychological and social support. Psychological capital ...
Read More
Background: Stress has been known as a risk factor for the onset and modification of autoimmune disorders such as myasthenia gravis (MG). However, the patients can control their stress and improve their quality of life (QOL) using some factors such as psychological and social support. Psychological capital and social support play a key role in decreasing stress and improving QOL in the patients with MG. Therefore, the present study aimed to assess the mediator role of the psychological capital and social support in perceived stress and QOL of the patients with MG.Methods: In the present cross-sectional study, 203 patients with MG, including 138 women and 65 men, were selected from Iran Myasthenia Gravis Association and Shariati Hospital, Tehran City, Iran, using available sampling. The selected patients completed the Myasthenia Gravis Quality of Life questionnaire (MG-QOL), Luthans Psychological Capital Questionnaire (PCQ), Multidimensional Scale of Perceived Social Support (MSPSS), and Cohen Perceived Stress Scale (PSS-14). To assess the mediator role of the psychological capital and the perceived social support in the relationship with the perceived stress and QOL of the patients with MG, structural equation modeling (SEM) was used.Results: There was a significant negative relationship between the perceived stress and the variables of psychological capital (including hope, resilience, optimism, and self-efficacy), perceived social support dimensions (including support from important people, support from family, and support from friends), and QOL dimensions (including social activity and mental health) (P < 0.01). The results also showed that the perceived social support dimensions (including support from important people, support from family, and support from friends) and the variables of psychological capital (including hope, resilience, optimism, and self-efficacy) had a significant positive relationship with the QOL in patients with MG (P < 0.01). The indirect effect of perceived stress on the QOL through social support and psychological capital was 0.16 and 0.15, respectively, which was statistically significant (P < 0.05).Conclusion: The present study results show that a part of the shared variance between the conceptual circles of the perceived stress and QOL in patients with MG results from variability in the psychological capital and social support.
Clinical Notes
Faramarz Roohollahi; Mohamadjavad Abbaspour; Mohamadreza Hajiabadi; Hiva Saffar; Morteza Faghih-Jouibari; Mostafa Farzin
Articles in Press, Accepted Manuscript, Available Online from 22 June 2024
Clinical Notes
Aviraj Satish Deshmukh; Ravinder Jeet Singh; Stuart McGregor; Stefano Maria Priola; Ruba Nabil Mahmoud Kiwan
Articles in Press, Accepted Manuscript, Available Online from 10 September 2024
Letter to the Editor
Francesco Natale; Riccardo Molinari; Noemi Mollo; Mirella Limatola; Lorenzo De Luca; Roberta Alfieri; Andrea Izzo; Giovanni Cimmino
Articles in Press, Accepted Manuscript, Available Online from 08 January 2024
Letter to the Editor
Jamal Hasoon; Christopher Robinson; Ivan Urits; Omar Viswanath
Articles in Press, Accepted Manuscript, Available Online from 27 December 2023
Letter to the Editor
Abdorreza Naser Moghadasi
Articles in Press, Accepted Manuscript, Available Online from 25 December 2023
Letter to the Editor
Ilkin Iyigundogdu; Eda Derle; Fatma Irem Yesiler
Articles in Press, Accepted Manuscript, Available Online from 26 September 2024
Neuroimage/Video
Lisle Blackbourn; Maher Salem; Deepak Nair
Articles in Press, Accepted Manuscript, Available Online from 26 September 2024
Clinical Notes
Cognitive neurology / Neuropsychiatry
Sajad Shafiee; Abbas Tafakhori; Mohammad Sadra Nemati; Saeed Kargar-Soleimanabad; Sobhan Alipour-Kiasar; Reza Yazdani-Cherati; Ahmadreza Hojati-Marvast; Omid Ahmadvand
Articles in Press, Accepted Manuscript, Available Online from 29 September 2024
Clinical Notes
Child neurology / Developmental Neurology
Sara Memarian; Golazin Shahbodagh-Khan; Masood Ghahvechi-Akbari; Elham Pourbakhtyaran; Saeid Samimiat; Mahmoudreza Ashrafi; Morteza Heidari
Articles in Press, Accepted Manuscript, Available Online from 03 October 2024
)
