Document Type : Review Article


1 Department of Neurology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Autoimmune Disease Research Center, Kashan University of Medical Sciences, Kashan, Iran

3 Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


Based on previous studies, seizure has been reported to accompany coronavirus disease 2019 (COVID-19). Underlying mechanisms are those leading to the direct central nervous system (CNS) invasion through hematogenous spread or trans-synaptic retrograde invasion, causing meningoencephalitis. On the other hand, there are pathophysiologic mechanisms that seizure would be one of their early consequences, such as cytokine storm, hypoxemia, metabolic derangement, and structural brain lesions. Herein, we focused on available evidence to provide an insight into the pathophysiologic mechanisms that link seizure and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as a better understanding of pathophysiology would lead to better diagnosis and treatment.


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