Original Article
1. Safety and efficacy of edaravone in well-defined Iranian patients with amyotrophic lateral sclerosis: A parallel-group single-blind trial

Alireza Eishi-Oskouei; Keivan Basiri

Volume 20, Issue 1 , Winter 2021, Pages 1-7

Abstract
  Background: This parallel-group single-blind trial evaluates the safety and efficacy of Edaravone, as a free radical scavenger, in a highly selective subgroup of Iranian patientswithamyotrophic lateral sclerosis (ALS). Methods: The study was registered in ClinicalTrials.gov (registration number: NCT03272802) ...  Read More

Original Article
2. Does vitamin D administration play a role in outcome of patients with acute ischemic stroke? A randomized controlled trial

Omidvar Rezaei; Mahtab Ramezani; Mehrdad Roozbeh; Bahareh Fazeli; Mohammadreza Hajiesmaeili; Hossein Pakdaman; Leila Simani

Volume 20, Issue 1 , Winter 2021, Pages 8-14

Abstract
  Background: Clinical studies have reported improved neurological outcomes in patients who were taking vitamin D supplements. This study investigates the effect of intramuscular (IM) vitamin D supplementation in patients with acute ischemic stroke (AIS) on neurological outcomes and inflammatory marker ...  Read More

Original Article
3. Economic sanctions against Iran as an important factor in threatening the health of patients with multiple sclerosis

Mohammad Ali Sahraian; Abdorreza Naser Moghadasi; Sharareh Eskandarieh

Volume 20, Issue 1 , Winter 2021, Pages 15-22

Abstract
  Background: After intensified economic sanctions against Iran, decreased welfare of patients were more recognizable. The present study was aimed at identifying the challenges and stress level experienced by patients with multiple sclerosis (MS) regarding treatment and health care services in 2018-2019 ...  Read More

Original Article
4. Evaluation of sexual self-efficacy and sexual function in women with multiple sclerosis in Mashhad, Iran, in 2019: A cross-sectional study

Elham Manouchehri; Morteza Saeedi; Khadijeh Mirzaei-Najmabadi

Volume 20, Issue 1 , Winter 2021, Pages 23-31

Abstract
  Background: In chronic illnesses, sexual dysfunction (SD) is one of the most prevalent complaints. Sexual self-efficacy (SSE) is an individual’s beliefs about his/her ability to perform an effective sexual function and be favorable to their partner. The aim of the present study was to assess SSE ...  Read More

Original Article
5. Mortality and morbidity in patients with spontaneous intracerebral hemorrhage: A single-center experience

Morteza Faghih-Jouybari; Mohammad Taghi Raof; Sina Abdollahzade; Sanaz Jamshidi; Tahereh Padeganeh; Saeid Ehteshami; Soroush Fateh

Volume 20, Issue 1 , Winter 2021, Pages 32-36

Abstract
  Background: Intracerebral hemorrhage (ICH) is the most common cause of non-ischemic strokes. Considering high mortality and poor functional status following ICH, we investigated factors that can predict short-term outcome and affect recovery of these patients. Methods: In this prospective descriptive ...  Read More

Original Article
6. Validating the Persian version of the amyotrophic lateral sclerosis-specific quality of life-revised instrument

Motahareh Afrakhteh; Sara Esmaeili; Mohsen Shati; Seyedeh Fahimeh Shojaei; Maryam Bahadori; Babak Zamani; Mostafa Almasi-Doghaee; Bahram Haghi-Ashtiani

Volume 20, Issue 1 , Winter 2021, Pages 37-42

Abstract
  Background: Amyotrophic Lateral Sclerosis-Specific Quality of Life-Revised (ALSSQOL-R) encompasses 50 items which assess quality of life (QOL) in patients with amyotrophic lateral sclerosis (ALS) in six major domains. This study aims to translate the ALSSQOL-R into Persian and evaluate its reliability ...  Read More

Review Article
7. Severe acute respiratory syndrome coronavirus 2 and seizure: An insight into the pathophysiologic mechanisms

Shima Zareh-Shahamati; Mahyar Noorbakhsh; Hadi Digaleh; Behnam Safarpour-Lima

Volume 20, Issue 1 , Winter 2021, Pages 43-48

Abstract
  Based on previous studies, seizure has been reported to accompany coronavirus disease 2019 (COVID-19). Underlying mechanisms are those leading to the direct central nervous system (CNS) invasion through hematogenous spread or trans-synaptic retrograde invasion, causing meningoencephalitis. On the other ...  Read More